摘要
由于具有优异的导电性、生物相容性、柔韧性和稳定性,聚(3,4-乙撑二氧噻吩):聚苯乙烯磺酸(PEDOT:PSS)导电水凝胶被广泛用于生物传感、神经电极及可穿戴电子等领域。但是,目前合成PEDOT:PSS导电水凝胶大都是通过大幅增加离子强度和降低pH改变PEDOT:PSS的聚集状态使其成胶,条件较苛刻。本文发现一种温和的PEDOT:PSS成胶方法,即通过对牛血清白蛋白(BSA)进行解折叠,改变空间构象,随后充分暴露的多肽链能够原位诱导PEDOT:PSS一步快速形成PEDOT:PSS/BSA互穿网络导电水凝胶。研究表明,该水凝胶不仅保持了PEDOT:PSS网络优异的导电性,同时解折叠的BSA赋予凝胶优异的溶胀性、力学性能和热性能。水凝胶溶血率均低于5%,表明其具有良好的细胞相容性,同时观察到该互穿凝胶能够在人体皮肤、橡胶、塑料和玻璃等多种基底材料上进行黏附,而且由于网络中大量的非共价键存在,该凝胶展现出优异的自愈合性能。总之,本文提供的PEDOT:PSS/BSA互穿网络水凝胶的制备方法及优异性能使其在可穿戴电子及伤口敷料等领域具有良好的应用前景。
By virtue of their excellent electrical conductivity,biocompatibility,flexibility and stability,poly(3,4-ethylenedioxythiophene):polystyrenesulfonic acid(PEDOT:PSS)conductive hydrogels have been widely used in biosensors,neural electrode and wearable bioelectronic devices,etc.However,researchers usually greatly increased ionic strength and lowered pH to change the aggregation state of PEDOT:PSS to synthesize PEDOT:PSS conductive hydrogels and to some extent this synthesis condition was harsh in consideration of its future application.In this paper,we provided a facile way to synthesize this conductive hydrogel,that is,bovine serum albumin(BSA)was introduced to induce PEDOT:PSS in situ by changing its spatial configuration to rapidly form a PEDOT:PSS/BSA interpenetrating network conductive hydrogel in one step.It was found that the hydrogel has inherited excellent electrical conductivity of PEDOT:PSS,and in the same time,the unfolded BSA endowed the hydrogel with good swelling and thermal properties.Moreover,the hydrogel has certain mechanical properties and excellent hemolysis rate.To our surprise,the hydrogel also exhibited good adhesion,and self-healing properties.In all,the synthesized method and excellent properties of PEDOT:PSS/BSA interpenetrated hydrogel we provided could have a wide potential in wearable bioelectronics and wound healing dressings.
作者
黄云锋
李德
王楠
马姣
HUANG Yunfeng;LI De;WANG Nan;MA Jiao(Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of Education,Taiyuan University of Technology,Taiyuan 030024,China;Key Laboratory for Medical Implantable Devices of Shandong Province,WEGO Holding Company Limited,Weihai 264210,China;State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China)
出处
《复合材料学报》
EI
CAS
CSCD
北大核心
2023年第9期5330-5340,共11页
Acta Materiae Compositae Sinica
基金
国家自然科学基金(51903185)。
