摘要
目的探讨红细胞分布宽度与血小板计数比值(RPR)与慢性阻塞性肺疾病(COPD)急性发作风险的相关性。方法选取2020年3月至2022年3月陕西省眉县中医医院收治的117例COPD患者作为COPD组,根据COPD患者是否出现急性发作分为急性发作组(43例)和非急性发作组(74例)。采用血细胞分析仪检测红细胞分布宽度(RDW)、血小板计数(PLT),并计算RPR;采用受试者工作特征曲线分析RPR对COPD急性发作的预测价值;采用多因素Logistic回归分析影响COPD急性发作的危险因素。结果急性发作组的RDW、RPR高于非急性发作组(P<0.05),PLT低于非急性发作组(P<0.05)。RPR预测COPD急性发作的曲线下面积为0.897(95%CI:0.847~0.947),截点值为0.13,特异度为83.58%,灵敏度为81.62%。急性发作组与非急性发作组的病程、吸烟、长期吸入药物、长期家庭氧疗情况,二氧化碳分压、氧分压、用力肺活量、第1秒用力呼气容积、第1秒用力呼气容积与用力肺活量比值比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,病程≥3年(OR=2.519,95%CI:1.666~3.810)、吸烟(OR=2.380,95%CI:1.589~3.564)、RPR≥0.13(OR=3.025,95%CI:1.905~4.805)是COPD急性发作的危险因素(P<0.05)。结论RPR在COPD急性发作患者中增加,能够作为预测COPD急性发作的生物学标志物,且RPR越高患者COPD急性发作的风险越高。
Objective To explore the correlation between the red blood cell distribution width(RDW)to platelet count ratio(RPR)and the onset risk of acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods A total of 117 cases of COPD admitted to Mei County Hospital of Traditional Chinese Medicine from March 2020 to March 2022 were selected as the COPD group and divided into non-acute exacerbation group(74 cases)and acute exacerbation group(43 cases)according to whether they had acute exacerbation.RDW and platelet count(PLT)were measured by the blood cell analyzer,and RPR was calculated.The predictive value of RPR for acute exacerbation of COPD was explored by the receiver operating characteristic(ROC)curve.The risk factors affecting acute exacerbation of COPD were analyzed by the multivariate Logistic regression.Results RDW and RPR in the acute exacerbation group were higher than those in the non-acute exacerbation group(P<0.05),and PLT was lower than that in the non-acute exacerbation group(P<0.05).The area under the curve(AUC)of RPR in predicting COPD acute exacerbation was 0.897(95%CI:0.847-0.947),the cut-off value was 0.13,the specificity was 83.58%,and the sensitivity was 81.62%.There were statistically significant differences in the course of disease,smoking,long-term inhaled drugs,long-term home oxygen therapy,PaCO 2,PaO 2,FVC,FEV_(1) and FEV_(1)/FVC between the acute exacerbation group and the non-acute exacerbation group(P<0.05).The multivariate Logistic regression analysis results showed that the disease duration≥3 years(OR=2.519,95%CI:1.666-3.810),smoking(OR=2.380,95%CI:1.589-3.564)and RPR≥0.13(OR=3.025,95%CI:1.905-4.805)were the risk factors for acute exacerbation of COPD(P<0.05).Conclusion RPR is increased in the patients with acute exacerbation of COPD,which could be used as a biological marker to predict acute exacerbation of COPD,moreover the higher the RPR,the higher the risk of acute exacerbation of COPD.
作者
张小娟
马昕
ZHANG Xiaojuan;MA Xin(Department of Clinical Laboratory,Mei County Hospital of Traditional Chinese Medicine,Baoji,Shaanxi 722300,China;Department of Medical Laboratory,Xianyang Municipal Central Hospital,Xianyang,Shaanxi 712000,China)
出处
《检验医学与临床》
CAS
2023年第19期2885-2888,共4页
Laboratory Medicine and Clinic
关键词
红细胞分布宽度
血小板计数
红细胞分布宽度与血小板计数比值
慢性阻塞性肺疾病
急性发作期
red blood cell distribution width
platelet count
ratio of red blood cell distribution width to platelet count
chronic obstructive pulmonary disease
acute exacerbation
