摘要
目的分析脓毒症患者淀粉样蛋白A(SAA)、降钙素原(PCT)、白蛋白(ALB)水平、系统免疫炎症指数(SII)评分、急性生理与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分、序贯器官衰竭(SOFA)评分与预后的相关性。方法回顾性分析2019年7月到2022年6月在陕西省人民医院诊治的100例脓毒症患者的临床资料。按照患者是否合并休克分为脓毒症组44例和脓毒症休克组56例,比较两组患者入院24 h的SAA、PCT、ALB水平和SII、APACHEⅡ、SOFA评分。按照28 d存活与否分为死亡组26例和生存组74例,比较两组患者入院24 h的SAA、PCT、ALB水平和SII、APACHEⅡ、SOFA评分。采用Spearman相关性分析法分析SAA、PCT、ALB水平及SII、APACHEⅡ、SOFA评分与预后的相关性。结果脓毒症休克组患者入院24 h的ALB水平为(21.58±4.49)g/L,明显低于脓毒症组的(37.09±6.25)g/L,SAA、PCT水平及SII、APACHEⅡ、SOFA评分分别为(473.81±90.47)mg/L、(68.90±12.21)μg/L、1463.26±105.29、(24.51±5.64)分、(19.56±5.02)分,明显高于脓毒症组的(350.23±95.14)mg/L、(50.38±11.42)μg/L、393.15±37.18、(10.52±3.11)分、(8.08±2.35)分,差异均有统计学意义(P<0.05);死亡组患者入院24 h的ALB水平为(17.46±3.95)g/L,明显低于存活组的(41.20±6.83)g/L,SAA、PCT水平及SII、APACHEⅡ、SOFA评分分别为(547.27±97.58)mg/L、(75.35±14.52)μg/L、2166.26±241.59、(27.84±6.36)分、(22.09±5.12)分,明显高于存活组(316.37±83.47)mg/L、(42.43±9.36)μg/L、273.29±56.27、(14.35±6.82)分、(13.51±4.55)分,差异均有统计学意义(P<0.05);经Spearman相关性分析结果显示,ALB与预后呈正相关(r=0.698,P<0.05),SAA、PCT、SII、APACHEⅡ、SOFA评分与预后呈负相关(r=-0.598、-0.607、-0.737、-0.564、-0.595,P<0.05)。结论脓毒症患者ALB水平明显高于脓毒症休克患者,SAA、PCT水平及SII、APACHEⅡ、SOFA评分明显低于脓毒症休克患者;脓毒症患者的ALB水平与预后呈正相关,SAA、PCT水平及SII、APACHE
Objective To analyze the relationship between the levels of serum amyloid A(SAA),procalcitonin(PCT),albumin(ALB),systemic immune inflammatory index(SII),acute physiology and chronic health evaluation Ⅱ(APACHEⅡ),sequential organ failure assessment(SOFA)and prognosis in patients with sepsis.Methods The clinical data of 100 patients with sepsis diagnosed and treated in Shaanxi Provincial People's Hospital from July 2019 to June 2022 were retrospectively analyzed.The patients were divided into sepsis group(44 cases)and septic shock group(56 cases)according to whether they had shock.The levels of SAA,PCT,ALB,and SII,APACHEⅡ,SOFA scores were compared between the two groups at 24 h after admission.According to death or survival within 28 d,they were divided into death group(26 cases)and survival group(74 cases).The levels of SAA,PCT,ALB and SII,APACHEⅡ,SOFA scores were compared between the two groups at 24 h after admission.Spearman correlation analysis was used to analyze the correlation between the levels of SAA,PCT,ALB,SII score,APACHEⅡ score,SOFA score and prognosis.Results The level of ALB in the septic shock group was(21.58±4.49)g/L at 24 h after admission,which was significantly lower than(37.09±6.25)g/L in the sepsis group;SAA,PCT,and SII,APACHⅡ,and SOFA scores were(473.81±90.47)mg/L,(68.90±12.21)μg/L,1463.26±105.29,(24.51±5.64)points,and(19.56±5.02)points,which were significantly higher than(350.23±95.14)mg/L,(50.38±11.42)μg/L,393.15±37.18,(10.52±3.11)points,(8.08±2.35)points in sepsis group(P<0.05).The level of ALB in the death group was(17.46±3.95)g/L at 24 h after admission,which was significantly lower than(41.20±6.83)g/L in the survival group;SAA,PCT,SII,APACHEⅡ,and SOFA scores were(547.27±97.58)mg/L,(75.35±14.52)μg/L,2166.26±241.59,(27.84±6.36)points,and(22.09±5.12)points,which were significantly higher than(316.37±83.47)mg/L,(42.43±9.36)μg/L,273.29±56.27,(14.35±6.82)points,(13.51±4.55)points in survival group;the differences were statistically significant(P<0.05)
作者
刘振国
白惠惠
王顺达
LIU Zhen-guo;BAI hui-hui;WANG Shun-da(Intensive Care Unit,Shaanxi Provincial People's Hospital,Xi'an 710068,Shaanxi,CHINA;Department of Rehabilitation Medicine,Shaanxi Provincial People's Hospital,Xi'an 710068,Shaanxi,CHINA)
出处
《海南医学》
CAS
2023年第17期2523-2526,共4页
Hainan Medical Journal
基金
陕西省自然科学基础研究项目(编号:2019JM-385)。
