摘要
类枯草杆菌蛋白酶-1(subtilisin-like protease,SUB1)是一种绝大多数顶复门原虫所必需的蛋白酶,SUB1广泛参与顶复门原虫的粘附、入侵、复制和逸出等多个生命活动。研究发现,SUB1属于丝氨酸蛋白酶家族,催化结构域保守,具有高度的专一性,并与虫体的运动和毒力相关。本文对已发现的顶复门原虫类枯草杆菌蛋白酶SUB1的结构和功能做一综述。
The subtilisin-like protease-1 is a essential protease for the majority of apicomplexa,and SUB1 is widely involved in multiple life activities,including adhesion,invasion,replication and egress.According to previous research,the SUBl is a serine protease that has highly specific catalytic domain and associated with motility and virulence of the parasites.We summarizes the structure and function of SUB1 in Apicomplexa.
作者
张欣
李瑾
谢金晶
孙慧
ZHANG Xin;LI Jin;XIE Jinjing;SUN Hui(Shandong Institute of Parasitic Diseases,Shandong First Medical University&Shandong Academy of Medical Sciences,Jining 272033,Shandong,China)
出处
《中国病原生物学杂志》
CSCD
北大核心
2023年第11期1364-1364,F0003,F0004,共3页
Journal of Pathogen Biology
基金
山东省自然科学基金(No.ZR2022MH271)
山东省医药卫生科技发展计划项目(No.202101050153)
山东省重点研发项目(No.2019GSF107054)
山东第一医科大学学术提升计划(No.2019QL005)。
