摘要
目的探讨影响Ⅰ型子宫内膜癌(EC)患者预后的因素。方法收集确诊的123例Ⅰ型EC患者的发病年龄、体质量指数(BMI)、手术方式、国际妇产科联合会(FIGO)分期、腹水细胞学、病理类型、术后辅助治疗方式及疗程等资料,用Kaplan-meier法进行单因素生存分析,Log-rank检验生存率差异,Cox多因素分析独立的预后因素。结果单因素分析显示年龄、绝经情况、BMI、FIGO分期、肌层浸润深度、淋巴结浸润、宫颈间质浸润、附件转移均与Ⅰ型EC患者预后有关(P<0.05);Cox多因素分析显示FIGO分期是影响Ⅰ型EC患者预后的独立危险因素(P<0.05);EC是否切除淋巴结不影响87例Ⅰ期EC患者预后(P=0.24);Ⅱ期及以上Ⅰ型EC术后不同辅助治疗方式对患者生存率的影响从生存曲线上未观察到差异(P>0.05)。结论FIGO分期是影响Ⅰ型EC预后的独立危险因素,淋巴结切除不能提高Ⅰ期EC患者的生存率。
Objective To explore the clinical influencing factors of prognosis in patients with typeⅠendometrial cancer(EC).Methods The clinical data on the onset age,body mass index(BMI),surgical method,international federation of gynecology and obstetrics(FIGO)stage,ascites cytology,pathological type,postoperative adjuvant treatment,and course of treatment from 123 patients with typeⅠEC were collected.The Kaplan-meier method was used for univariate survival analysis,Log-rank test for survival difference,and Cox multivariate analysis for independent prognostic factors.Results Univariate analysis showed that age,menopause,BMI,FIGO stage,depth of myometrial invasion,lymph node invasion,cervical interstitial invasion,and adnexal metastasis were all associated with the prognosis of patients with typeⅠEC(P<0.05).Cox multivariate analysis showed FIGO stage was the independent risk factor affecting the prognosis of patients with typeⅠEC(P<0.05).Eighty-seven of the 123 patients with typeⅠEC were in stageⅠ,and the removal of lymph nodes did not affect the prognosis of 87 patients with typeⅠEC(P=0.24).In this study no statistical difference was found in the survival rates of patients with stageⅡof typeⅠEC in the different postoperative adjuvant therapies on the survival curve(P>0.05).Conclusion FIGO stage was the independent risk factor affecting the prognosis of patients with typeⅠEC.And the removal of lymph nodes does not affect the survival rates of the patients with typeⅠEC.
作者
周远利
李丹青
杨英捷
ZHOU Yuanli;LI Danqing;YANG Yingjie(Department of Gynecology and Oncology,the Affiliated Cancer Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China)
出处
《贵州医科大学学报》
CAS
2023年第9期1088-1091,1099,共5页
Journal of Guizhou Medical University
基金
贵州省卫生健康委科学技术基金(gzwkj2021-307)。
关键词
子宫肿瘤
内膜样腺癌
手术
调查
预后
uterine tumor
endometrioid cancer
surgical operation
investigation
prognosis
