摘要
目的探讨乌拉地尔(URA)配合自拟天麻川芎汤治疗高血压危象(HPC)患者的临床效果。方法选取2019年12月至2021年12月青岛市即墨区第二人民医院收治的120例HPC患者作为研究对象,根据随机卡片表法按照1∶1比例均衡分为西药组(n=60,给予URA治疗)和中西组(n=60,给予URA治疗+自拟天麻川芎汤)。比较两组患者临床疗效、中医证候积分、血压和心率变化、血液流变学指标以及不良反应发生率。结果中西组治疗有效率明显高于西药组,差异有统计学意义(P<0.05);与治疗前比较,治疗4周后两组中医证候积分均明显降低(P<0.05),且中西组明显低于西药组,差异有统计学意义(P<0.05);治疗1h、6h后,两组收缩压、舒张压及心率均明显降低(P<0.05),且中西组收缩压、舒张压均明显低于西药组(P<0.05),而两组治疗后心率比较,差异无统计学意义(P>0.05);与治疗前比较,治疗4周后两组患者全血高切黏度、全血低切黏度、纤维蛋白原均明显降低(P<0.05),且中西组明显低于西药组(P<0.05);治疗期间,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论URA配合自拟天麻川芎汤治疗HPC,可明显改善患者症状,提升疗效,降低机体血液黏稠度,且不良反应少。
Objective To explore the clinical effects of urapidil(URA)combined with self-made Tianma Chuanqiong decoction in treating patients with hypertensive crisis(HPC).Methods Totally 120 patients with HPC who were treated in the Second People's Hospital of Jimo District from December 2019 to December 2021 were enrolled as the study subjects and were divided into western medicine group(n=60,URA treatment)and Chinese-western medicine group(n=60,URA treatment+self-made Tianma Chuanqiong decoction)according to the random card table method in a 1:1 ratio.The clinical efficacy,TCM syndromes scores,blood pressure and heart rate changes,hemorheological indicators and incidence rates of adverse drug reactions were compared between the two groups.Results The effective rate in Chinese-western medicine group was significantly higher than that in western medicine group(P<0.05).After 4 weeks of treatment,the scores of TCM syndromes in the two groups were significantly decreased compared with those before treatment(P<0.05),and the scores in Chinese-western medicine group were significantly lower than those in western medicine group(P<0.05).At 1 hour and 6 hours after treatment,the systolic blood pressure,diastolic blood pressure and heart rate were declined significantly in the two groups(P<0.05),and the systolic blood pressure and diastolic blood pressure at 1 hour and 6 hours afer treatment were significantly lower in Chinese-western medicine group than those in western medicine group(P<0.05),but there was no statistical difference in heart rate between the two groups(P>0.05).After 4 weeks of treatment,whole blood high tangential viscosity,whole blood low tangential viscosity and fibrinogen were significantly reduced in the two groups compared to before treatment(P<0.05),and the above three indicators in Chinese-western medicine group were significantly lower than those in western medicine group(P<0.05).During the treatment,there was no statistically significant difference in the incidence rate of adverse reactions between the two
作者
刘元超
王秀娟
LIU Yuan-Chao;WANG Xiu-Juan(Department of Pharmacy,The Second People's Hospital of Jimo District,Qingdao 266200,China)
出处
《中国药物经济学》
2023年第8期72-75,共4页
China Journal of Pharmaceutical Economics
关键词
乌拉地尔
自拟天麻川芎汤
高血压危象
血液流变学
Urapidil
Self-made Tianma Chuanqiong decoction
Hypertensive crisis
Hemorheology
