摘要
卵巢癌是临床较为常见的一种疾病,治疗方法包括手术治疗与化疗。其中,铂类药物是化疗的首选药物,具有细胞周期非特异性特征,能够与DNA结合并形成加合物,改变DNA结构,使其原有的复制转录功能出现障碍,进而引发细胞死亡,可应用于大部分卵巢癌患者,但在治疗过程中存在耐药现象。铂类化疗药物出现耐药的主要原因较为复杂,包括DNA损伤与修复、药物转运、药物代谢、肿瘤微环境、细胞死亡抑制等。本文主要针对卵巢癌铂耐药机制及靶向治疗进行综述。
Ovarian cancer is a common clinical disease,with treatment methods of surgical treatment and chemotherapy.Platinum drugs are the preferred chemotherapy drugs,with non-specific characteristics of cell cycle,can form adducts combined with DNA,change DNA structure,disrupt its original replication and transcription function and cause cell death,which can be applied to most ovarian cancer patients.However,there is resistance during treatment process.Main reasons for platinum chemocurative drugs resistance are complicated,including DNA damage and repair,drug transport,drug metabolism,tumor microenvironment,cell death inhibition,etc.The article reviews mechanism of platinum resistance and targeted therapy in ovarian cancer.
作者
刘南南
宋桂红
吕升扬
LIU Nannan;Song Guihong;LV Shengyang(Department of Medicine,Shandong College of Traditional Chinese Medicine,Yantai,Shandong 264100)
出处
《智慧健康》
2023年第18期52-55,61,共5页
Smart Healthcare
关键词
卵巢癌
铂类耐药
靶向治疗
化疗
Ovarian cancer
Platinum resistance
Targeted therapy
Chemothe rapy
