摘要
目的探讨吡格列酮联合阿司匹林在糖尿病伴代谢综合征中的治疗效果。方法选择2020年4月—2023年2月广西桂平市人民医院收治的85例糖尿病伴代谢综合征患者为研究对象,采用随机抽签法分为对照组42例与研究组43例,对照组患者给予阿司匹林治疗,研究组患者则联合吡格列酮治疗,对比两组患者的肥胖、血糖、血脂相关指标水平变化以及各炎性因子水平变化,并评价两组患者得用药安全性。结果两组治疗后体质指数与腰臀比均降低,且研究组低于对照组,差异有统计学意义(P<0.05)。两组治疗后各血糖相关指标水平均降低,且研究组低于对照组,差异有统计学意义(P<0.05)。两组治疗后高密度脂蛋白胆固醇水平均升高,低密度脂蛋白胆固醇、三酰甘油、脂蛋白相关磷脂酶及总胆固醇水平均降低,且研究组均优于对照组,差异有统计学意义(P<0.05)。两组治疗后的各炎性因子水平均降低,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组不良反应的总发生率为9.30%高于对照组的4.76%,但差异无统计学意义(χ^(2)=0.155,P>0.05)。结论吡格列酮联合阿司匹林可有效改善糖脂代谢,减轻体质量,抑制机体炎症,且安全性较好,对糖尿病伴代谢综合征的治疗就有积极的作用。
Objective To investigate the effect of pioglitazone combined with aspirin in the treatment of diabetes melli⁃tus with metabolic syndrome.Methods 85 cases of diabetes patients with metabolic syndrome admitted to Guiping People's Hospital in Guangxi from April 2020 to February 2023 were selected as the research objects.They were ran⁃domly divided into a control group of 42 cases and a study group of 43 cases.The patients in the control group were treated with aspirin,while the patients in the study group were treated with pioglitazone.The changes of obesity,blood glucose,blood lipid related indicators and inflammatory factors in the two groups were compared,And evaluate the medication safety of both groups of patients.Results After treatment,body mass index and waist-to-hip ratio de⁃creased in both groups,and the study group was lower than the control group,the difference was statistically signifi⁃cant(P<0.05).After treatment,the levels of various blood glucose related indicators in both groups decreased,and the study group was lower than the control group,the difference was statistically significant(P<0.05).After treatment,the levels of high-density lipoprotein-cholesterol increased in both groups,while the levels of low density lipoprotein-cholesterol,triglyceride,lipoprotein-associated phospholipaseA2,and total cholesterol decreased.The study group was superior to the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of various inflammatory factors in both groups decreased,and the study group was lower than the control group,the dif⁃ference was statistically significant(P<0.05).The total incidence of adverse reactions in the study group was 9.30%higher than that in the control group,which was 4.76%,but the difference was not statistically significant(χ2=0.155,P>0.05).Conclusion Pioglitazone combined with aspirin can effectively improve glucose and lipid metabolism,reduce body weight,inhibit body inflammation,and have a good safety,and have a positive eff
作者
李彬
伍军伟
凌俊宏
谭欣
LI Bin;WU Junwei;LING Junhong;TAN Xin(Department of Endocrinology,Guiping People's Hospital,Guiping,Guangxi Zhuang Autonomous Region,537200 China)
出处
《系统医学》
2023年第13期112-115,共4页
Systems Medicine
