摘要
脂滴(lipid droplets, LDs)是储存中性脂质的细胞器,与脂质蓄积息息相关。长链脂酰辅酶A合成酶3 (long chain acyl-coenzyme A synthetase 3, ACSL3)是一种LDs相关蛋白,在细胞中主要分布于细胞膜、内质网和细胞内LDs,且分布依赖于细胞类型和脂肪酸供应。ACSL3是脂肪酸代谢的关键调节因子,与细胞内脂质积累密切相关,在LDs的合成与脂质代谢、细胞炎症、铁死亡等多种病理生理过程中发挥着重要作用。本文主要综述ACSL3在脂质合成、铁死亡和炎症反应等过程中发挥的作用,着重阐述ACSL3在动脉粥样硬化脂质蓄积中的作用机制,为发现动脉粥样硬化疾病中新的潜在治疗靶点提供新的思路。
Lipids droplets are organelles that store neutral lipids and are closely related to lipid accumulation. Long chain acyl-coenzyme A synthetase 3(ACSL3) is a lipid droplet-associated protein mainly distributed in the cell membrane, endoplasmic reticulum,and intracellular lipid droplets, and its distribution depends on cell type and fatty acid supply. ACSL3 is a key regulator of fatty acid metabolism that is closely related to intracellular lipid accumulation, and plays an important role in various pathophysiological processes such as lipid droplet synthesis and lipid metabolism, cellular inflammation, and ferroptosis. This paper mainly reviews the role of ACSL3 in lipid synthesis, ferroptosis, and inflammatory response, with focus on the mechanism of its role in lipid accumulation in atherosclerosis, and provides new ideas for exploring potential therapeutic targets in atherosclerotic diseases.
作者
杨丽
袁中华
YANG Li;YUAN Zhong-Hua(Institute of Cardiovascular Disease,Key Laboratory for Arteriosclerology of Hunan Province,Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease,Hengyang Medical School,University of South China,Hengyang 421001,China)
出处
《生理学报》
CAS
CSCD
北大核心
2023年第4期587-594,共8页
Acta Physiologica Sinica
基金
supported by the National Natural Science Foundation of China (No. 81973326)。
关键词
长链脂酰辅酶A合成酶3
动脉粥样硬化
脂质蓄积
脂滴
long chain acyl-coenzyme A synthetase 3(ACSL3)
atherosclerosis
lipid accumulation
lipid droplet
