摘要
目的系统评价肺癌患者并发肺部真菌感染的危险因素.方法系统检索CNKI、Wanfang、VIP、CBM、PubMed、Embase和The Cochrane Library,搜集有关肺癌患者并发肺部真菌感染危险因素的病例-对照研究和队列研究.检索时限从2007年1月-2022年10月.由2名研究者独立进行文献筛选、资料提取和质量评价,采用Rev Man 5.3软件进行Meta分析.结果共检索到24篇符合纳入与排除标准的文献,共计7349例肺癌患者.对18个潜在危险因素进行Meta分析,结果显示,年龄≥60岁、体力活动状态(PS)评分≥2分、吸烟史、高血压、糖尿病、贫血、TNM分期为Ⅲ-Ⅳ期、放疗、放化疗、侵入性操作、住院时间>14天、使用糖皮质激素和使用抗菌药物是肺癌患者发生肺部真菌感染的危险因素(均P<0.05).结论肺癌患者发生肺部真菌感染危险因素较多.早期识别肺癌患者发生肺部真菌感染的危险因素,并制定防治措施,有利于降低肺部真菌感染发病率.受纳入文献数量和质量限制,上述结论需要更多高质量研究予以验证.
OBJECTIVE To systematically evaluate the risk factors for pulmonary fungal infection in lung cancer patients.METHODS The databases including CNKI,Wanfang,VIP,CBM,PubMed,Embase and the Cochrane Library were systematically retrieved to collect the case-control studies and cohort studies about the risk factors for pulmonary fungal infection in lung cancer patients.The searching time limit was'from Jan 2007 to Oct 2022.The screening of literatures,extraction of data and quality evaluation were carried out independently by two researchers.The meta-analysis was performed by using Rev Man 5.3 software.RESULTS A total of 24 literatures that conformed to the inclusion and exclusion criteria were retrieved,with totally 7349 lung cancer patients involved.The meta-analysis was performed for 18 potential risk factors,and the result showed that no less than 60 years of age,Performance status(PS)score no less than 2 points,smoking history,hypertension,diabetes mellitus,anemia,Ⅲ-Ⅳ TNM stage,radiotherapy,chemoradiotherapy,invasive operation,length of hospital stay more than 14 days,use of glucocorticoids and use of antibiotics were the risk factors for the pulmonary fungal infection in the lung cancer patients(all P<O.05).CONCLUSION There are a variety of risk factors for the pulmonary fungal infection in the lung cancer patients.Early identification of the risk factors and implementation of prevention measures may reduce the incidence of pulmonary fungal infection.More high-quality studies are needed to verify the a-bove conclusion due to the limits of quantity and quality of literatures.
作者
李泽云
刘城鑫
郭泽怀
李佩芹
杨建英
曹洋
LI Ze-yun;LIU Cheng-xin;GUO Ze-huai;LI Pei-qin;YANG Jian-ying;CAO Yang(The First Clinical Medical School,Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510405,China;不详)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2023年第17期2575-2580,共6页
Chinese Journal of Nosocomiology
基金
国家自然科学基金面上项目(81973815,82174456)。
