摘要
肥胖胰岛素抵抗常导致多种症状,危害人类健康。随着肥胖发病率的逐年升高,肥胖胰岛素抵抗导致的记忆损害逐渐受到重视。中医手法在缓解胰岛素抵抗、改善记忆损害当中取得了良好效果,其具体机制可总结为改善炎症反应、修复线粒体功能、调控神经突触、调节肠道微生物群和脑神经细胞的凋亡来改善记忆损害。总结其机制研究的相关进展,对探讨未来研究导向及临床治疗策略的完善具有积极意义。
Obesity insulin resistance often leads to a variety of symptoms that are harmful for human health.With the increase of obesity incidence rate year by year,the memory impairment caused by obesity insulin resistance has gradually attracted attention.Traditional Chinese medicine techniques have achieved good results in alleviating insulin resistance and improving memory impairment.The specific mechanisms of them can be summarized as improving the inflammatory response,repairing mitochondrial function,regulating neurosynapses,and regulating intestinal microbiota and apoptosis of brain nerve cells to improve memory impairment.It is of positive significance to summarize the relevant progress of the mechanism research to explore the future research orientation and the improvement of clinical treatment strategy.
作者
姜荣生
高天姣
太宇星
崔建中
张龙
姚兰英
刘明军
JIANG Rongsheng;GAO Tianjiao;TAI Yuxing;CUI Jianzhong;ZHANG Long;YAO Lanying;LIU Mingjun(Changchun University of Chinese Medicine,Changchun 130117,China)
出处
《长春中医药大学学报》
2023年第10期1160-1164,共5页
Journal of Changchun University of Chinese Medicine
基金
国家自然科学基金(82174525)
吉林省科技发展计划项目(YDZJ202201ZYTS195)。
关键词
中医手法
肥胖
胰岛素抵抗
记忆损害
Chinese medicine manipulation
obesity
insulin resistance
memory impairment
