摘要
目的:研究肺纤维支气管镜细胞病理学检查技术对肺癌患者的临床诊断价值,为临床早期诊断肺癌提供理论依据。方法:回顾性分析2021年1月—2022年2月武陟济民医院收治的170例肺癌患者的临床资料,所有患者均进行肺纤维支气管镜细胞病理学检查,对比手术病理结果,分析肺纤维支气管镜细胞病理学检查与手术病理结果,分析肺纤维支气管镜细胞病理学检查技术对肺癌患者的临床诊断价值。结果:170例患者经手术病理检查发现,其中鳞癌患者84例(49.41%),腺癌患者59例(34.71%),小细胞癌患者27例(15.88%)。刷片对鳞癌和腺癌的诊断阳性率高于灌洗液,而联合检查对小细胞癌的诊断阳性率高于刷片和灌洗液,可见肺纤维支气管镜刷片和灌洗液联合检查对肺癌的诊断阳性率更高,差异有统计学意义(χ^(2)=32.082、29.377、5.132、63.605,P<0.05)。刷片可见鳞癌细胞胞浆丰富、嗜酸性,且细胞核较大,HE染色细胞核颜色较深,可见“蛇形”细胞;腺癌细胞呈乳头样结构,胞浆丰富且细胞核较大,细胞核染色较深,异型性明显;鳞癌细胞可见成片的细胞核深染色,异型细胞堆积重叠,细胞结构不易辨识;小细胞癌可见较多红细胞及少量的核深染,稍退变异型细胞,数量较少,不易诊断。灌洗液可见腺癌细胞胞浆嗜双色,细胞核较大、色深,且大小不一;小细胞癌呈裸核样,细胞核颜色深染,核质细腻,大小不一。结论:肺纤维支气管镜细胞病理学检查技术能有效检测出肺癌的疾病类型,两种细胞病理学检测方式联合检测能进一步提高肺癌的检出率。
Objective:To study the clinical diagnostic value of lung fiberoptic bronchoscopy cytopathological examination tech⁃nique for lung cancer patients and provide theoretical basis for early clinical diagnosis of lung cancer.Methods:The clinical data of 170 patients with lung cancer admitted to the hospital from January 2021 to February 2022 were retrospectively analyzed,and all patients underwent pulmonary fiberoptic bronchoscopy cytopathology.The results of surgical pathology were compared and the results of pulmonary fiberoptic bronchoscopy cytopathology and surgical pathology and their clinical diagnostic value for patients with lung cancer were analyzed.Results:Surgical pathological examination of 170 patients revealed 84 patients(49.41%)with squamous carcinoma,59 patients(34.71%)with adenocarcinoma,and 27 patients(15.88%)with small cell carcinoma.The positive diagnostic rate of brush smear for squamous carcinoma and adenocarcinoma was higher than that of lavage,while the positive diag⁃nostic rate of combined examination for small cell carcinoma was higher than that of brush smear and lavage,which showed that the combined examination of lung fiberoptic bronchoscopy brush smear and lavage had a higher positive diagnostic rate for lung cancer,and the difference was statistically significant(χ^(2)=32.082,29.377,5.132,63.605,P<0.05).The brush shows that squa⁃mous carcinoma cells have abundant cytoplasm,eosinophilic and large nuclei,with darker nuclei and“snake-like”cells in HE staining.Adenocarcinoma cells showed papillary-like structure,abundant cytoplasm and large nuclei,with darker nuclear staining and obvious heterogeneity.Squamous carcinoma cells showed patches of darkly stained nuclei with overlapping heterotypic cells,and the cell structure was not easily recognizable.Small cell carcinoma can be seen as more erythrocytes and a small number of darkly stained nuclei,slightly regressed heterogeneous cells,which are less in number and not easily diagnosed.The cytoplasm of adenocarcinoma cells was seen t
作者
林燕燕
李洋洋
Lin Yanyan;Li Yangyang(Department of Pathology,Wuzhi Jimin Hospital,Jiaozuo,Henan,454950,China)
出处
《黑龙江医学》
2023年第20期2460-2462,共3页
Heilongjiang Medical Journal
基金
河南省医学科技攻关项目(2020176251)。
关键词
肺纤维支气管镜
细胞病理学检查
手术病例
肺癌
诊断
Pulmonary fiberoptic bronchoscopy
Cytopathological examination
Surgical cases
Lung cancer
Diagnosis
