摘要
纳米晶的制备工艺简单、载药量高、黏附性强,可有效解决水难溶性药物滞留时间短、释放速度慢、生物利用度低等问题,已成为近年来药剂学领域研究的热点。该文就纳米晶的制备技术及其应用于鼻腔、眼部、口腔、皮肤、肺部等黏膜给药系统的研究进展进行综述,以期为难溶性药物纳米晶制剂的研发提供参考依据。
Owing to simple preparation process,high drug loading capacity and strong adhesion,nanocrystals can effectively solve the problems of short-term retention time,slow release rate and low bioavailability of poorly watersoluble drugs.Therefore,it has become a hot research topic in pharmaceutics in recent years.In this paper,the preparation technologies of nanocrystals and their research progress of applications in mucosal drug delivery systems such as nasal,ocular,oral,skin and pulmonary delivery systems are reviewed,hoping to provide a reference basis for the development of nanocrystal-based dosage forms of poorly soluble drugs.
作者
马月琴
李刚
肖汉扬
岳鹏飞
张增珠
MA Yueqin;LI Gang;XIAO Hanyang;YUE Pengfei;ZHANG Zengzhu(Dept.of Pharmaceutics,908th Hospital of Joint Logistics Support Force of PLA,Nanchang 330000;Key Lab.of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004)
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2023年第7期1042-1051,共10页
Chinese Journal of Pharmaceuticals
关键词
水难溶性药物
纳米晶
制备技术
黏膜给药
应用
poorly water-soluble drug
nanocrystal
preparation technology
mucosal drug delivery
application
