摘要
鲍曼不动杆菌是一种多重耐药的机会致病菌,其致病机制复杂多样,对人类健康造成了严重威胁,故研究其致病机制势在必行。细菌运动不仅在细菌的迁移中起作用,还与其毒力、耐药性、黏附性、趋化性及生物膜形成等密切相关。鲍曼不动杆菌因缺乏鞭毛早期被认为不具备运动性,然而随着研究的深入发现其可通过蹭行运动及表面相关运动在潮湿的表面移动,影响其运动性的因素主要包括IV型菌毛、群体感应、外排泵、趋化系统及蓝光感应等。本文主要就鲍曼不动杆菌的运动性、影响因素及运动性的生物学作用展开讨论,并为鲍曼不动杆菌感染的预防及治疗提供参考。
Acinetobacter baumannii is a multi-drug resistant opportunistic pathogen.Its pathogenic mechanism is complex and diverse,which has posed a major threat to human health.Therefore,it is imperative to investigate its pathogenic mechanism.Bacterial motility not only plays a role in the migration of bacteria,but is also closely related to virulence,drug resistance,adhesion,chemotaxis and biofilm formation.The lack of flagella caused Acinetobacter baumannii to be thought non-motile for a long time,but further research had revealed that it could move across the wet surface by twitching and surface-associated motility.The factors affecting motility mainly include type IV pili,quorum sensing,efflux pumps,chemotaxis and blue light.This article discussed the motility,influencing factors and biological effects of motility of Acinetobacter baumannii,and provided a reference for its treatment and prevention.
作者
张玲玲
成婷婷
王崇刚
ZHANG Lingling;CHENG Tingting;WANG Chonggang(Department of Infectious Diseases,The Second Clinical Medical College of Shanxi Medical University,Taiyuan 030001,Shanxi Province,China;Department of Respiratory Medicine,Taiyuan Xishan Hospital,Taiyuan 030001,Shanxi Province,China)
出处
《微生物与感染》
CAS
2023年第2期123-128,共6页
Journal of Microbes and Infections
基金
山西省应用基础研究计划(20210302123279)。
关键词
鲍曼不动杆菌
运动性
IV型菌毛
自然转化能力
Acinetobacter baumannii
Motility
Type IV pili
Natural transformation ability
