摘要
目的探讨血清过氧化还原蛋白1(PRDX1)、脂蛋白相关磷脂酶A2(Lp-PLA2)、生存素(Survivin)水平变化与急性缺血性脑卒中(AIS)患者美国国立卫生研究院卒中量表(NIHSS)评分的相关性及临床意义。方法选取许昌医院2020年12月—2022年9月收治的125例AIS患者为研究对象,根据入院时NIHSS评分将患者分为轻度组(n=46,NIHSS<4分)、中度组(n=52,4分≤NIHSS≤15分)、重度组(n=27,NIHSS>15分),根据治疗后90 d改良Rankin量表(mRS)评分将患者分为预后良好(n=86,mRS≤2分)和预后不良(n=39,mRS>2分)两个亚组。比较3组(入院时)血清PRDX1、Lp-PLA2、Survivin水平与NIHSS评分相关性;对比不同预后患者(入院时、治疗7 d、14 d)血清各指标水平;对比各指标不同水平对AIS患者预后不良的危险度。结果轻度组血清PRDX1、Lp-PLA2、Survivin低于中度组,中度组各指标低于重度组,与NIHSS评分均呈正相关,差异有统计学意义(P<0.05);治疗7 d、14 d后,预后不良患者血清PRDX1、Lp-PLA2、Survivin水平高于预后优良患者,差异有统计学意义(P<0.05);治疗7 d、14 d后高水平患者预后不良危险度是低水平患者2.134、3.280、2.677倍/3.693、4.917、3.497倍,差异有统计学意义(P<0.05)。结论血清PRDX1、Lp-PLA2、Survivin水平变化与AIS患者NIHSS评分密切相关,能为临床病情判断及预后评估提供参考依据。
Objective To investigate the correlation and clinical significance of serum peroxiredoxin 1(PRDX1),lipoprotein-associated phospholipase A2(Lp-PLA2)and Survivin levels with National Institutes of Health Stroke Scale(NIHSS)score in patients with acute ischemic stroke(AIS).Methods A total of 125 AIS patients admitted to Xuchang Hospital from December 2020 to September 2022 were selected as the research objects.According to the NIHSS score at admission,the patients were divided into mild group(n=46,NIHSS<4 points),moderate group(n=52,4 points≤NIHSS≤15 points),and severe group(n=27,NIHSS>15 points).According to the modified Rankin scale(mRS)score at 90 days after treatment,the patients were divided into two subgroups:good outcome(n=86,mRS≤2)and poor outcome(n=39,mRS>2).The correlation between serum PRDX1,Lp-PLA2,Survivin levels and NIHSS score was compared among the three groups(at admission).The levels of serum indexes in patients with different prognosis(at admission,7 days and 14 days after treatment)were compared.The risk of poor prognosis in AIS patients with different levels of each index was compared.Results The levels of PRDX1,Lp-PLA2 and Survivin in mild group were lower than those in moderate group,and those in moderate group were lower than those in severe group,and they were positively correlated with NIHSS score(P<0.05).After 7 and 14 days of treatment,the serum levels of PRDX1,Lp-PLA2 and Survivin in patients with poor prognosis were higher than those in patients with good prognosis,and the differences were statistically significant(P<0.05).After 7 days and 14 days of treatment,the risk of poor prognosis of patients with high level was 2.134,3.280,2.677 times/3.693,4.917,3.497 times of patients with low level,and the difference was statistically significant(P<0.05).Conclusion The changes of serum PRDX1,Lp-PLA2 and Survivin levels are closely related to NIHSS score in patients with AIS,which can provide reference for clinical condition judgment and prognosis evaluation.
作者
周津津
王丽娟
辛梦
ZHOU Jin-jin;WANG Li-juan;XIN Meng(Department of Neurolgy,Xuchang Hospital,Xuchang,Henan,461000,China)
出处
《中国血液流变学杂志》
CAS
2023年第2期182-185,共4页
Chinese Journal of Hemorheology
