摘要
目的:探讨保留乳头乳晕的改良根治术治疗对乳腺癌患者远处转移率及生命质量的影响。方法:纳入2021年2月至2022年4月济南市中西医结合医院收治的拟择期手术治疗乳腺癌的患者84例进行分组研究。按照随机数字表法的分组方式将患者分成保留乳头乳晕组与常规根治术组,每组各42例。常规根治术组患者应用常规根治术进行治疗,保留乳头乳晕组患者应用保留乳头乳晕的改良根治术进行治疗。比较两组的围术期指标、随访1年远处转移率、手术前后的FACT-B评分。结果:(1)两组患者的手术时间、术中出血量、淋巴结清扫数量、住院时间比较,差异无统计学意义(P>0.05)。(2)随访1年内的肿瘤远处转移率:保留乳头乳晕组转移2例,转移率4.76%;常规根治术组转移9例,转移率21.43%。保留乳头乳晕组的远处转移率低于常规根治术组(P<0.05)。(3)两组患者术前各项FACT-B评分的差异无统计学意义(P>0.05);术后6个月两组患者的各项FACT-B评分均较术前提高,且保留乳头乳晕组的各项FACT-B评分均高于常规根治术组(P<0.05)。结论:采取保留乳头乳晕的改良根治术治疗乳腺癌可以取得良好的治疗效果,对控制肿瘤的转移及提升患者的生命质量有积极作用。
Objective:To investigate the effect of modified radical resection with nipple and areola preservation on the rate of distant metastasis and quality of life in patients with breast cancer.Methods:From February 2021 to April 2022,84 patients with breast cancer undergoing elective surgery in Jinan Hospital of Integrated Traditional Chinese and Western Medicine were included in the group study.According to the random number table method,the patients were divided into nipple areola preservation group and conventional radical operation group,with 42 cases in each group.The patients in the conventional radical operation group were treated with conventional radical operation,and the patients in the papillary areola-preserving group were treated with modified radical operation.Perioperative indexes,1-year follow-up rate of distant metastasis and FACT-B scores before and after surgery were compared between the two groups.Results:(1)There was no significant difference in operation time,intraoperative blood loss,number of lymph node dissection and hospital stay between the two groups(P>0.05).(2)The rate of distant metastasis within 1 year of follow-up:2 cases(4.76%)in the papillary areola preserving group;In the conventional radical operation group,9 patients had metastasis(21.43%).The rate of distant metastasis in the papillary areola preserving group was lower than that in the conventional radical operation group(P<0.05).(3)There was no significant difference in FACT-B scores between the two groups before surgery(P>0.05);Six months after surgery,FACT-B scores in both groups were higher than those before surgery,and FACT-B scores in the papillareola preserving group were higher than those in the conventional radical operation group(P<0.05).Conclusion:The modified radical resection with the preservation of nipple and areola in the treatment of breast cancer can achieve a good therapeutic effect,which has a positive effect on controlling the metastasis of tumor and improving the quality of life of patien ts.
作者
刘汉东
LIU Handong(Jinan Hospital of Integrated Chinese and Western Medicine,Jinan 271199,Shandong,China)
关键词
乳腺癌
保留乳头乳晕的改良根治术
远处转移率
生命质量
breast cancer
Modified radical operation to preserve nipple a reola
Distant metastasis rate
Quality of life
