摘要
目的探讨肿块型乳腺癌多模态核磁共振(MRI)影像表现及其与人表皮生长因子受体(CerbB-2)、雌激素受体(ER)、孕激素受体(PR)相关性分析。方法将海南西部中心医院2018年6月至2022年5月收治的90例乳腺癌患者纳入研究对象,全部患者入院后均行钼靶X线和多模态MRI检查。比较钼靶X线和多模态M RI对肿块型乳腺癌的检出率与诊断效能,并评估肿块型乳腺癌多模态MRI表现与细胞蛋白CerbB-2、ER、PR的表达阳性率,进而分析肿块型乳腺癌多模态MRI表现与细胞蛋白CerbB-2、ER、PR的表达统计结果。结果90例患者通过病理检查检出肿块型乳腺癌患者58例,其检出率是64.44%;钼靶X线对肿块型乳腺癌的检出率是68.97%;多模态MRI对肿块型乳腺癌的检出率是87.93%;病理检查结果作为金标准,多模态MRI对肿块型乳腺癌的灵敏度、准确度、阴性预测值均高于钼靶X线对肿块型乳腺癌(P<0.05)。钼靶X线和多模态MRI对肿块型乳腺癌的特异度、阳性预测值比较,差异无统计学意义(P>0.05);经病理证实为肿块型乳腺癌患者58例,CerbB-2阳性者30例,ER阳性者35例,PR阳性者33例。Pearson相关性分析结果为肿块型乳腺癌肿块边缘与ER、PR阳性表达呈正相关,后方回声与ER阳性表达呈正相关,血供情况与CerbB-2阳性表达呈正相关,微小钙化与CerbB-2、PR阳性表达呈正相关,淋巴结转移与Cerb B-2阳性表达呈正相关,淋巴结转移与ER、PR阳性表达呈负相关(P<0.05)。结论多模态MRI对肿块型乳腺癌具有较高的灵敏度、准确度、阴性预测值,其肿块边缘、后方回声、血供情况、微小钙化、淋巴结转移的影像表现与CerbB-2、ER、PR具有相关性,对临床诊断、治疗肿块型乳腺癌意义重大。
Objective To investigate the multimodal magnetic resonance imaging(MRI)manifestations of mass type breast cancer and its correlation with human epidermal growth factor receptor(CerbB-2),estrogen receptor(ER)and progesterone receptor(PR).Methods 90 patients with mass type breast cancer in Hainan West Central Hospital from June 2018 to may 2022 were included in the study.All patients underwent molybdenum target X-ray and multimodal MRI after admission.To compare the detection rate and diagnostic efficacy of molybdenum target X-ray and multimodal MRI in mass type breast cancer,and to evaluate the multimodal MRI manifestations of mass type breast cancer and the positive rate of expression of cellular proteins CerbB-2,ER and PR,and then to analyze the statistical results of multimodal MRI manifestations of mass type breast cancer and the expression of cellular proteins CerbB-2,ER and PR.Results 58 of 90 patients with mass breast cancer were detected by pathological examination,and the detection rate was 64.44%;The detection rate of mass type breast cancer by molybdenum target X-ray was 68.97%;The detection rate of multimodal MRI for mass type breast cancer was 87.93%;As the gold standard,the sensitivity,accuracy and negative predictive value of multimodal MRI for mass type breast cancer were higher than those of molybdenum target X-ray for mass type breast cancer(P<0.05).There was no significant difference between molybdenum target X-ray and multimodal MRI in the specificity and positive predictive value of mass type breast cancer(P>0.05);58 patients with mass breast cancer were confirmed by pathology,of which 30 were CerbB-2 positive,35 were ER positive,and 33 were PR positive.Pearson correlation analysis showed that the edge of mass breast cancer was positively correlated with ER and PR positive expression,the posterior echo was positively correlated with ER positive expression,blood supply was positively correlated with CerbB-2 positive expression,microcalcification was positively correlated with CerbB-2 and PR pos
作者
李小玲
黄文荣
李开成
LI Xiao-ling;HUANG Wen-rong;LI Kai-cheng(Department of Radiology,Hainan West Central Hospital,Danzhou 571700,Hainan Province,China;Department of Radiology,The Ninth People's Hospital of Shanghai Jiaotong University Medical College,Shanghai 200011,China)
出处
《中国CT和MRI杂志》
2023年第9期111-113,共3页
Chinese Journal of CT and MRI
基金
海南省卫生计生行业科研项目(1806032031A2001)。
关键词
肿块型乳腺癌
多模态核磁共振
人表皮生长因子受体
雌激素受体
孕激素受体
Mass Type Breast Cancer
Multimodal Nuclear Magnetic Resonance
Human Epidermal Growth Factor Receptor
Estrogen Receptor
Progesterone Receptor
