摘要
目的:探讨双嘧达莫联合丙种球蛋白及阿司匹林治疗对川崎病(Kawasaki disease,KD)患者冠状动脉病变、改善临床症状、降低炎性因子、提高免疫反应的作用。方法:选取2020年1月—2022年1月本院确诊的80例KD患儿作为研究对象,按照随机数字表法分为观察组(n=40)及对照组(n=40)。观察组采用静注丙种球蛋白联合口服阿司匹林肠溶片联合双嘧达莫片治疗,对照组采用静注丙种球蛋白联合口服阿司匹林肠溶片治疗,比较两组临床疗效、症状改善时间、炎性因子、免疫指标、不良反应情况及冠状动脉病变发生情况。结果:观察组治疗总有效率为92.50%,高于对照组的75.00%(P<0.05);观察组退热、黏膜充血、淋巴肿大症状、躯干红斑改善时间均短于对照组(P<0.05);观察组IL-6、CRP、TNF-α水平低于对照组(P<0.05);观察组IgG、IgM水平高于对照组、补体C3水平低于对照组(P<0.05);两组不良反应发生率、冠状动脉病变发生率比较,差异无统计学意义(P>0.05)。结论:双嘧达莫联合丙种球蛋白及阿司匹林治疗川崎病疗效显著,有助于降低炎性因子反应、遏制机体免疫系统异常活化,安全性较好。
Objective:To investigate the effect of dipyridamole combined with gamma globulin and aspirin on coronary artery disease,clinical symptoms,inflammatory factors and immune response in patients with Kawasaki disease(KD).Methods:A total of 80 children with KD diagnosed in our hospital from January 2020 to January 2022 were selected as the research objects and divided into observation group(n=40)and control group(n=40)according to the random number table method.The observation group was treated with intravenous immunoglobulin combined with oral aspirin enteric-coated tablets combined with dipyridamole tablets,while the control group was treated with intravenous immunoglobulin combined with oral aspirin enteric-coated tablets.The clinical efficacy,symptom improvement time,inflammatory factors,immune indexes,adverse reactions and coronary artery lesions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 92.50%,which was higher than 75.00%in the control group(P<0.05).The improvement time of fever,mucosal congestion,lymphadenopathy and trunk erythema in the observation group was shorter than that in the control group(P<0.05).The levels of IL-6,CRP and TNF-αin the observation group were lower than those in the control group(P<0.05).The levels of IgG and IgM in the observation group were higher than those in the control group,and the level of complement C3 was lower than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions and coronary artery disease between the two groups(P>0.05).Conclusion:Dipyridamole combined with gamma globulin and aspirin is effective in the treatment of Kawasaki disease,which is helpful to reduce the response of inflammatory factors and curb the abnormal activation of the immune system,with good safety.
作者
武海江
孙永法
陈清
WU Haijiang;SUN Yongfa;CHEN Qing(Department of Pediatrics,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471009,Henan,China)
出处
《中国药物滥用防治杂志》
CAS
2023年第9期1576-1580,共5页
Chinese Journal of Drug Abuse Prevention and Treatment
基金
河南省医学科技攻关计划联合共建项目(编号:LHGJ20191212)。
关键词
川崎病
免疫功能
双嘧达莫
丙种球蛋白
Kawasaki disease
Immune function
Dipyridamole
Gamma globulin
