摘要
目的采用营养不良全球领导人倡议(Global Leadership Initiative on Malnutrition,GLIM)标准评估进展期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者营养不良的患病情况,分析其相关因素,并探讨合并营养不良对进展期NSCLC患者在多方面的不利影响。方法回顾性收集2021年1月-12月在四川大学华西医院上锦医院肿瘤科首次住院治疗的进展期NSCLC患者作为研究对象。根据GLIM标准对所有患者进行营养不良评估,分析患者合并营养不良现状及相关因素,使用Barthel指数量表比较营养不良与非营养不良患者日常生活活动能力,使用生命质量核心量表比较两组患者生活质量,利用医院信息系统病程记录比较两组患者抗肿瘤治疗首次不良反应情况。结果共纳入285例进展期NSCLC患者。根据GLIM诊断标准,285例患者中有134例(47.0%)诊断为营养不良。二分类多因素logistic回归分析结果显示,年龄[60~69 vs.<60岁:比值比(odds ratio,OR)=2.323,95%置信区间(confidence interval,CI)(1.277,4.397);≥70 vs.<60岁:OR=10.816,95%CI(4.185,27.959)]、既往病史[OR=2.740,95%CI(1.313,5.717)]、白蛋白水平[OR=0.905,95%CI(0.848,0.965)]是进展期NSCLC患者合并营养不良的相关因素(P<0.05)。营养不良组患者日常生活活动能力、生活质量均劣于非营养不良组[(87.57±12.48)vs.(91.82±6.77)分,P<0.05;(76.22±11.52)vs.(83.96±9.75),P<0.05],不良反应发生率高于非营养不良组(50.7%vs.31.8%,P<0.05)。结论进展期NSCLC患者营养不良患病率较高,高龄、既往病史、白蛋白是进展期NSCLC患者合并营养不良的相关因素,营养不良对进展期NSCLC患者的活动能力、生命质量以及抗肿瘤治疗不良反应等方面会产生不良影响。
Objective To assess the prevalence of malnutrition in patients with advanced non-small cell lung cancer(NSCLC)using the Global Leadership Initiative on Malnutrition(GLIM)criteria,analyze its associated factors,and explore the adverse effects of malnutrition on advanced NSCLC patients in multiple aspects.Methods Patients with NSCLC who were hospitalized for the first time in the Department of Oncology,Shangjin Hospital,West China Hospital,Sichuan University between January and December 2021 were retrospectively selected as the study objects.Malnutrition assessment was carried out in all patients according to GLIM criteria,and the current situation and related factors of malnutrition were analyzed.The Barthel index scale was used to compare the daily activity ability between the malnourished group and the non-malnourished group,the Quality-of-Life Questionnaire-Core 30 scale was used to compare the quality of life between the two groups,and the adverse reactions of the two groups were compared by the hospital information system course records.Results According to GLIM diagnostic criteria,134 of 285 patients(47.0%)were diagnosed with malnutrition.The results of binary multiple logistic regression analysis showed that age[60-69 vs.<60 years old:odds ratio(OR)=2.323,95%confidence interval(CI)(1.277,4.397);≥70 vs.<60 years old:OR=10.816,95%CI(4.185,27.959)],previous medical history[OR=2.740,95%CI(1.313,5.717)],and albumin level[OR=0.905,95%CI(0.848,0.965)]were associated with malnutrition in patients with advanced NSCLC(P<0.05).The daily activity ability and quality of life in the malnourished group were significantly worse than those in the non-malnourished group(87.57±12.48 vs.91.82±6.77,P<0.05;76.22±11.52 vs.83.96±9.75,P<0.05),and the incidence of adverse reactions in the malnourished group was higher than that of the non-malnourished group(50.7%vs.31.8%,P<0.05).Conclusions The prevalence of malnutrition in patients with advanced NSCLC is high,and advanced age,previous medical history and albumin are related f
作者
谢灵灵
罗小珍
吴驭
雷莹
张雪梅
XIE Lingling;LUO Xiaozhen;WU Yu;LEI Ying;ZHANG Xuemei(Center of Geriatrics,West China Hospital,Sichuan University/West China School of Nursing,Sichuan University,Chengdu,Sichuan 610041,P.R.China;Department of Oncology,Chengdu Shangjin Nanfu Hospital/Shangjin Hospital,West China Hospital,Sichuan University,Chengdu,Sichuan 610000,P.R.China)
出处
《华西医学》
CAS
2023年第9期1354-1359,共6页
West China Medical Journal
基金
四川省科技计划项目(2021JDKP0100)。
关键词
进展期非小细胞肺癌
营养不良全球领导人倡议
营养不良
相关因素
Advanced non-small cell lung cancer
Global Leaders Initiative on Malnutrition
malnutrition
related factors
