摘要
目的中药可调控核因子κB(NF-κB)信号通路在体内的表达而抑制炎症反应,同时还通过影响NF-κB与其他信号因子的相互关联来改善糖尿病心肌病(DCM)的心肌损伤。本文从NF-κB及相关因子着手,综述其在DCM中的病理机制及中药干预研究,旨在为中药防治DCM提供理论参考。
Chinese herbs can suppress inflammatory responses by modulating the expression of the nuclear factorκB(NF-κB)signaling pathway in vivo and also ameliorate myocardial injury in diabetic cardiomyopathy(DCM)by affecting the interconnection of NF-κB with other signaling factors.This paper reviews the pathological mechanism of NF-κB and related factors in DCM and herbal intervention studies,aiming to provide theoretical references for the prevention and treatment of DCM with Chinese medicine.
作者
李晓艳
杨丽霞
梁永林
朱向东
高艳奎
LI Xiao-yan;YANG Li-xia;LIANG Yong-lin;ZHU Xiang-dong;GAO Yan-kui(Clinical College of Traditional Chinese Medicine,Lanzhou 730000,Gansu Province,China;School of Basic Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,Gansu Province,China;Central Laboratory,Gansu Academy of Traditional Chinese Medicine,Lanzhou 730000,Gansu Province,China;College of Traditional Chinese Medicine,Ningxia Medical University,Yinchuan 750000,Ningxia Hui Autonomous Region,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2023年第16期2423-2427,共5页
The Chinese Journal of Clinical Pharmacology
基金
甘肃省教育厅-产业支撑计划基金资助项目(2021CYZC-03)。
关键词
中药
糖尿病心肌病
核因子ΚB
traditional Chinese medicine
diabetic cardiomyopathy
nuclear factor-kappa B
