摘要
目的:观察冠心宁片联合常规西药治疗冠状动脉非阻塞性心肌梗死(MINOCA)的临床疗效。方法:选取60例MINOCA患者,按随机数字表法分为观察组和对照组各30例。对照组采取常规西药治疗,观察组在对照组基础上加用冠心宁片治疗。比较2组治疗前后心绞痛症状、心功能指标、睡眠质量、心电图变化,统计2组心血管事件发生率。结果:观察组心电图疗效总有效率为96.67%,高于对照组80.00%(P<0.05)。治疗后,2组心绞痛症状评分及匹兹堡睡眠质量指数量表(PSQI)评分较治疗前降低(P<0.05),且观察组心绞痛症状评分及PSQI评分低于对照组(P<0.05)。治疗后,2组心肌肌钙蛋白I (cTnI)、肌酸激酶同工酶(CK-MB)及N末端脑钠肽前体(NT-proBNP)水平较治疗前降低(P<0.05),且观察组cTnI、CK-MB及NT-proBNP水平低于对照组(P<0.05)。观察组心血管事件发生率为6.67%,低于对照组26.67%,差异有统计学意义(P<0.05)。结论:冠心宁片联合常规西药治疗MINOCA患者疗效和安全性均较高,可有效减轻患者心脏缺血,改善患者心绞痛症状,提高睡眠质量,降低心血管事件发生率。
Objective:To observe the clinical effect of Guanxinning Pills combined with routine western medicine for myocardial infarction with non-obstructive coronary arteries(MINOCA).Methods:A total of 60 cases of MINOCA patients were selected and divided into the observation group and the control group according to the random number table method,with 30 cases in each group.The control group was treated with routine western medicine,and the observation group was additionally treated with Guanxinning Pills based on the treatment of the control group.The changes in angina pectoris symptoms,cardiac function indicators,sleep quality,and electrocardiogram were compared before and after treatment between the two groups.The incidence of cardiovascular events in the two groups was counted.Results:The total curative effective rate of electrocardiogram was 96.67%in the observation group,higher than that of 80.00%in the control group(P<0.05).After treatment,the scores of angina pectoris symptoms and Pittsburgh Sleep Quality Index (PSQI) in the two groups were decreased when compared with those beforetreatment (P<0.05),and the scores of angina pectoris symptoms and PSQI in the observation group werelower than those in the control group (P<0.05). After treatment, the levels of cardiac troponin I (cTnI),creatine kinase- MB (CK- MB), and N- terminal pro B- type natriuretic peptide (NT- proBNP) in the twogroups were decreased when compared with those before treatment (P<0.05),and the the three levels inthe observation group were lower than those in the control group (P<0.05). The incidence of cardiovascularevents was 6.67% in the observation group,lower than that of 26.67% in the control group,the differencebeing significant (P<0.05). Conclusion: Guanxinning Pills combined with routine western medicine hasrelatively high curative effects and safety in the treatment of MINOCA,and can effectively alleviate heartischemia in patients, improve angina pectoris symptoms, enhance sleep quality, and reduce theincidence of cardiovascular events.
作者
陆燕萍
何超杰
LU Yanping;HE Chaojie(Department of Cardiovascular Medicine,The First Hospital of Jiaxing,Jiaxing Zhejiang 314000,China)
出处
《新中医》
CAS
2023年第15期49-53,共5页
New Chinese Medicine
基金
浙江省医药卫生科技计划项目(2021KY1105)
浙江省医学会临床科研基金项目(2020ZYC-A45)。
关键词
冠状动脉非阻塞性心肌梗死
冠心宁片
心绞痛
心电图
睡眠质量
心功能
Myocardial infarction with non-obstructive coronary arteries
Guanxinning Pills
Angina pectoris
Electrocardiogram
Sleep quality
Cardiac function
