摘要
目的:分析钠-葡萄糖协同转运蛋白2(sodium-glucose linked transporter 2,SGLT-2)抑制剂+膳食纤维及聚焦治疗对2型糖尿病肾病的效果,预期SGLT2抑制剂联合膳食纤维饮食辅助阶段式聚焦治疗能够进一步改善2型糖尿病肾病的发生发展,为防治2型糖尿病肾病并发症提供临床循证依据。方法:选取2021年1月—2022年8月赣南医学院第一附属医院收治的2型糖尿病肾病患者共100例,随机分为对照组、观察组,各50例。对照组运用SGLT-2抑制剂联合膳食纤维饮食治疗;观察组在对照组的基础上,加用阶段式聚焦治疗。比较两组临床疗效,治疗前后视黄醇结合蛋白、血清胱抑素C、血糖、肾功能(肾小球滤过率、24 h尿微量白蛋白、尿白蛋白/肌酐)、炎症指标。结果:观察组总有效率高于对照组(P<0.05)。治疗前两组视黄醇结合蛋白、血清胱抑素C、血糖、肾功能、炎症指标差异均无统计学意义(P>0.05)。治疗后两组视黄醇结合蛋白、血清胱抑素C、血糖、24 h尿微量白蛋白、尿白蛋白/肌酐、炎症指标均低于治疗前,而肾小球滤过率高于治疗前,且观察组均优于对照组(P<0.05)。结论:SGLT-2抑制剂+膳食纤维及聚焦治疗对2型糖尿病肾病的效果确切,可降低机体炎症指标,改善血糖和肾功能,降低视黄醇结合蛋白、血清胱抑素C水平。
Objective:To analyze the effect of sodium glucose linked transporter 2(SGLT-2)inhibitor+dietary fiber and focused therapy on type 2 diabetes nephropathy,and to predict that SGLT2 inhibitor combined with dietary fiber diet assisted phased focused therapy can further improve the occurrence and development of type 2 diabetes nephropathy,and provide clinical evidence for prevention and treatment of type 2 diabetes nephropathy complications.Method:A total of 100 patients with type 2 diabetes nephropathy admitted to First Affiliated Hospital of Gannan Medical University from January 2021 to August 2022 were selected.They were randomly divided into the control group and the observation group,with 50 patients in each group.The control group was treated with SGLT-2 inhibitor combined with dietary fiber;on the basis of the control group,the observation group was treated with stage focused therapy.The clinical efficacy,retinol binding protein,serum cystatin C,blood glucose,renal function(glomerular filtration rate,24-hour urinary microalbumin,urinary albumin/creatinine),and inflammatory indicators before and after treatment between the two groups were compared.Result:The total effective rate of the observation group was higher than that of the control group(P<0.05).There were no statistically significant differences in retinol binding protein,serum cystatin C,blood glucose,renal function,and inflammatory indicators between the two groups before treatment(P>0.05).After treatment,the levels of retinol binding protein,serum cystatin C,blood glucose,24-hour urinary microalbumin,urinary albumin/creatinine,and inflammatory markers in both groups were lower than before treatment,while the glomerular filtration rate was higher than before treatment,and the observation group were better than the control group(P<0.05).Conclusion:SGLT-2 inhibitor+dietary fiber and focused therapy have a definite effect on type 2 diabetes nephropathy,which can reduce the body inflammatory indicators,improve blood glucose and renal function,and reduce t
作者
邹芳琴
刘书凤
罗娟
严文君
刘勋华
ZOU Fangqin;LIU Shufeng;LUO Juan;YAN Wenjun;LIU Xunhua(First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China;不详)
出处
《中国医学创新》
CAS
2023年第25期42-46,共5页
Medical Innovation of China
基金
江西省卫生健康委科技计划项目(202310727)。
