摘要
目的分析拉莫三嗪联合丙戊酸钠治疗对小儿癫痫发作控制情况及发作频率的影响。方法60例小儿癫痫患儿,采用随机数字表法将其分为观察组与对照组,各30例。对照组仅接受丙戊酸钠治疗,观察组则接受丙戊酸钠联合拉莫三嗪治疗。比较两组临床疗效、不良反应发生情况以及治疗前后的脑电图结果、癫痫发作情况、血清炎性因子水平、实验室指标水平。结果观察组治疗总有效率96.67%高于对照组的73.33%,差异具有统计学意义(P<0.05)。治疗后,观察组每180秒累及导联数(3.43±1.04)次低于对照组的(5.68±1.69)次、每180秒癫痫样放电次数(7.33±2.13)次、癫痫发作频次(0.53±0.22)次/个月少于对照组的(11.44±3.28)次、(1.02±0.29)次/个月,癫痫发作持续时间(2.02±0.58)min/次短于对照组的(2.79±0.77)min/次,差异具有统计学意义(P<0.05)。治疗后,观察组C反应蛋白(CRP)(4.87±0.54)mg/L、白细胞介素(IL)-2(3.23±0.48)ng/ml、IL-6(7.08±1.27)pg/ml、TNF-α(28.57±4.46)ng/L均低于对照组的(8.01±0.97)mg/L、(4.93±0.57)ng/ml、(18.41±2.69)pg/ml、(55.64±6.29)ng/L,差异具有统计学意义(P<0.05)。治疗后,观察组同型半胱氨酸(HCY)(10.75±1.83)μmol/L、S-100β蛋白(0.38±0.07)μg/L、神经元特异性烯醇化酶(NSE)(12.13±1.82)μg/L均低于对照组的(16.33±2.04)μmol/L、(0.61±0.14)μg/L、(20.08±2.04)μg/L,差异具有统计学意义(P<0.05)。观察组不良反应发生率3.33%低于对照组的26.67%,差异具有统计学意义(P<0.05)。结论采用拉莫三嗪与丙戊酸钠联合治疗小儿癫痫能取得显著疗效,能让神经元损伤及炎性反应有效减轻,进而对小儿癫痫发作进行有效控制,具有较高的安全性,值得推广。
Objective To analyze the effect of lamotrigine combined with sodium valproate treatment on seizure control and seizure frequency in pediatric epilepsy.Methods A total of 60 cases of pediatric epilepsy were divided into observation group and control group according to the random numerical table,with 30 cases in each group.The control group was treated with sodium valproate,and the observation group was treated wotj sodium valproate and lamotrigine.The clinical efficacy,occurrence of adverse reactions,electroencephalogram results,seizures,serum inflammatory factors and laboratory indexes were compared between the two groups.Results The total effective rate of the observation group was 96.67%,which was higher than that of 73.33%of the control group,and the difference was statistically significant(P<0.05).After treatment,the number of involved leads per 180 s of(3.43±1.04)times in the observation group was lower than that of(5.68±1.69)times in the control group;the number of epileptiform discharges per 180 s of(7.33±2.13)times and seizure frequency of(0.53±0.22)times per month in the observation group were less than those of(11.44±3.28)times and(1.02±0.29)times per month in the control group;the duration of seizures of(2.02±0.58)min/time in the observation group was shorter than that of(2.79±0.77)min/time in the control group;the differences were statistically significant(P<0.05).After treatment,the observation group had C-reactive protein(CRP)of(4.87±0.54)mg/L,interleukin-2 of(3.23±0.48)ng/ml,IL-6 of(7.08±1.27)pg/ml,and TNF-αof(28.57±4.46)ng/L,which were lower than those of(8.01±0.97)mg/L,(4.93±0.57)ng/ml,(18.41±2.69)pg/ml,and(55.64±6.29)ng/L in the control group,and the differences were statistically significant(P<0.05).After treatment,the observation group had homocysteine(HCY)of(10.75±1.83)μmol/L,S-100βprotein of(0.38±0.07)μg/L,and neuron-specific enolase(NSE)of(12.13±1.82)μg/L,which were lower than those of(16.33±2.04)μmol/L,(0.61±0.14)μg/L,and(20.08±2.04)μg/L in the control group,a
作者
全新建
QUAN Xin-jian(Department of Pediatrics,Shunchang County Hospital,Nanping 353200,China)
出处
《中国现代药物应用》
2023年第17期154-157,共4页
Chinese Journal of Modern Drug Application
关键词
拉莫三嗪
丙戊酸钠
小儿癫痫
控制情况
发作频率
Lamotrigine
Sodium valproate
Pediatric epilepsy
Control
Seizure frequency
