摘要
目的探讨慢性乙型肝炎病毒(HBV)感染对妊娠期糖尿病(GDM)孕妇的妊娠并发症、孕晚期生殖道B族链球菌(GBS)感染情况以及妊娠结局的影响。方法选取2020年1月1日-12月31日在广州市妇女儿童医疗中心定期产检、足月、单胎妊娠的GDM孕妇共583例,其中合并HBV感染者(GDM+HBV组)48例,无合并者(GDM组)535例。比较2组的妊娠期并发症、妊娠晚期(妊娠35~37周)生殖道GBS感染情况、妊娠结局以及阴道分娩者的母儿结局。结果与GDM组患者相比,GDM+HBV组患者出现妊娠期肝内胆汁淤积症、孕晚期生殖道GBS感染者比例较高,孕期出现胎盘早剥者比例较高,阴道分娩过程中出现产时发热、羊水粪染和新生儿入住NICU者比例均较高(均P<0.05)。结论与无合并慢性HBV感染的GDM患者相比,合并慢性HBV感染的GDM患者在围产期的母儿风险升高。
Objective To investigate the effects of chronic hepatitis B virus(HBV)infection on pregnancy complications,group B streptococcus(GBS)infection in third trimester and pregnancy outcome in pregnant women with gestational diabetes mellitus(GDM).Methods A retrospective study of 583 pregnant women with GDM,singleton gestation and cephalic presentation delivered at term in Guangzhou Women and Children’s Medical Center was carried out.Including 48 GDM women complicated with chronic HBV infection(GDM+HBV group)and 535 GDM women without HBV infection(GDM group).Pregnancy complications,GBS infection in third trimester(gestation 35-37 weeks),pregnancy outcomes,maternal and neonatal outcomes of vaginal delivery were compared between the two groups.Results GDM+HBV group had a higher proportion of intrahepatic cholestasis of pregnancy(ICP)and GBS infection in third trimester than GDM group,and a higher proportion of placental abruption during pregnancy.GDM+HBV group showed a significantly increased proportion in intrapartum fever,meconium-stained amniotic fluid and neonatal intensive care unit admission during vaginal delivery than GDM group(all P<0.05).Conclusions GDM women with chronic HBV infection are associated with increased maternal and fetal risk during pregnancy and delivery.
作者
赵己未
沙晓燕
伍金娟
吴雪
张国正
ZHAO Jiwei;SHA Xiaoyan;WU Jinjuan;WU Xue;ZHANG Guozheng(Department of Gastroenterology,Jinshazhou Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510000,China;Department of Obstetrics,Guangzhou Women and Children’s Medical Center,Guangzhou 510623,China)
出处
《广州医药》
2023年第9期11-15,共5页
Guangzhou Medical Journal
基金
国家自然科学基金(81701456)。
关键词
妊娠期糖尿病
慢性乙型肝炎病毒感染
B族链球菌感染
妊娠结局
gestational diabetes mellitus
chronic hepatitis B virus infection
group B streptococcus infection
pregnancy outcomes
