摘要
急性高原病(acute mountain sickness,AMS)是人体急性暴露于高原低压低氧环境后出现多系统生理紊乱的临床综合征。定量蛋白质组学技术可以系统定量并描述机体蛋白质组成和动态变化规律,近年来在多种疾病的预防、诊断、治疗和发生机制等方面研究应用广泛。本文系统综述了定量蛋白质组学技术及其在AMS的预防、诊断、治疗和急进高原习服机制研究中的应用进展,以期为AMS的发病机制、提前干预、临床治疗和AMS的蛋白质组学研究提供参考。
Acute mountain sickness(AMS)is a clinical syndrome of multi-system physiological disorder after acute exposure to low pressure and low oxygen at high altitude.Quantitative proteomics can systematically quantify and describe protein composition and dynamic changes.In recent years,quantitative proteomics has been widely used in the prevention,diagnosis,treatment and pathogenesis of many diseases.This review summarizes the progress of quantitative proteomics techniques and its application in the prevention,diagnosis,treatment of AMS and mechanisms of rapidly acclimatizing to plateau,in order to provide a reference for the pathogenesis,early intervention,clinical treatment and proteomic research of AMS.
作者
涂博丹
魏雪
尚慧莹
刘作旭
王一豪
高月
TU Bodan;WEI Xue;SHANG Huiying;LIU Zuoxu;WANG Yihao;GAO Yue(School of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,Jiangxi,China;Institute of Radiation Medicine,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)
出处
《生物工程学报》
CAS
CSCD
北大核心
2023年第9期3594-3604,共11页
Chinese Journal of Biotechnology
基金
国家自然科学基金(82204774)
国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTDD-202207)。
关键词
定量蛋白质组学
急性高原病
高原习服
生物标志物
低压低氧
quantitative proteomics
acute mountain sickness
plateau acclimatization
biomarkers
hypobaric hypoxia
