摘要
目的研究低频重复经颅磁刺激(rTMS)对颅脑外伤(TBI)患者认知功能及P300电位的影响。方法纳入2019年12月至2021年6月江苏省南通市第一人民医院神经外科和康复医学科住院的50例TBI患者,根据随机数字表法将其分为试验组及对照组,各25例。两组均接受临床基础治疗及常规的认知功能训练,试验组在此基础上增加低频rTMS治疗,对照组辅以假刺激治疗,连续治疗6周。比较治疗前后简易智能精神状态评价检查量表(MMSE)、洛文斯顿认知评定量表(LOTCA)、P300波幅和潜伏期;观察治疗期间不良反应的发生情况。结果治疗后,两组定向力、记忆力、回忆能力、注意力和计算力、语言能力及MMSE总分高于治疗前,且试验组定向力、注意力与计算力及MMSE总分高于对照组,差异有统计学意义(P<0.05)。治疗后,两组定向、视知觉、空间知觉、动作运用、视运动组织、思维操作、注意力及专注力及LOTCA总分高于治疗前,且试验组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组P300波幅大于治疗前、潜伏期短于治疗前;且试验组P300波幅大于对照组、潜伏期短于对照组,差异有统计学意义(P<0.05)。两组治疗过程中均未出现癫痫等不良反应。结论低频rTMS能够改善TBI患者的认知功能,值得临床应用推广,P300可客观体现rTMS对认知的改善效果。
Objective To investigate the effects of low-frequency repetitive transcranial magnetic stimulation(rTMS)on cognitive function and P300 potential in patients with traumatic brain injury(TBI).Methods A total of 50 TBI patients hospitalized in the Department of Neurosurgery and Rehabilitation Medicine,Nantong First People’s Hospital of Jiangsu Province from December 2019 to June 2021 were selected,and they were divided into experimental group and control group,with 25 cases in each group according to the random number table method.Both groups received clinical basic treatment and conventional cognitive function training,and the experimental group was supplemented with low-frequency rTMS treatment,while control group was given sham stimulation treatment,continuous treatment for six weeks.The mini-mental state examination(MMSE)score,Loewenstein occupational therapy cognitive assessment(LOTCA)score,and P300 amplitude and latency were compared before and after treatment,the occurrence of adverse reactions during treatment was observed.Results After treatment,the scores of orientation,memory,recall,attention and computation,language ability,and MMSE total score of two groups were higher than those before treatment,and the scores of orientation,attention and computation,and MMSE total score of experimental group were higher than those of control group,and the differences were statistically significant(P<0.05).After treatment,the scores of orientation,visual perception,spatial perception,motor use,visual motor organization,thinking operation,attention and concentration,and LOTCA total score in two groups were higher than those before treatment,and those of experimental group were higher than those of control group,and the differences were statistically significant(P<0.05).After treatment,P300 amplitude was larger than that before treatment,and latency was shorter than that before treatment,and P300 amplitude in experimental group was higher than that in control group,and latency was shorter than that in control group,and
作者
翟佳佳
徐倩
韩珍真
胡臻妮
王梁
郭冠兰
卢红建
ZHAI Jiajia;XU Qian;HAN Zhenzhen;HU Zhenni;WANG Liang;GUO Guanlan;LU Hongjian(Department of Rehabilitation Medicine,the Second Affiliated Hospital of Nantong University,Jiangsu Province,Nantong 226001,China)
出处
《中国医药导报》
CAS
2023年第26期95-99,共5页
China Medical Herald
基金
江苏省卫生健康委员会科研项目(M2021106)
江苏省南通市科技项目(MS12018064)。
关键词
颅脑外伤
认知功能障碍
P300电位
经颅磁刺激
Traumatic brain injury
Cognitive function dysfunction
P300 potential
Transcranial magnetic stimulation
