摘要
结缔组织病相关肺间质病变是临床较常见的风湿免疫疾病,其病因病机不明,对患者带来了巨大的家庭和社会负担。实验动物模型是结缔组织病相关肺间质病变(connective tissue disease-interstitial lung disease,CTD-ILD)研究领域中不可或缺的一部分,成功建立符合人类疾病发生发展进程的动物模型对于疾病的机制研究和治疗药物的开发具有重要意义。因此,本文通过汇总国内外CTD-ILD相关动物模型文献,总结模型构建方法、特点及不足等,以期为相关领域的研究者选择合适动物模型提供参考。
Connective tissue disease-interstitial lung disease is a common clinical rheumatic immune disease.Its etiology and pathogenesis are unknown,which causes a significant family and social burden to patients.Animal models are indispensable for research of CTD-ILD.Successful establishment of an animal model in line with the development of human disease is important to study the disease mechanism and develop therapeutic drugs.Therefore,by summarizing domestic and foreign literature on animal models related to CTD-ILD,this article summarizes the method,characteristics and shortcomings of model establishment to provide reference for researchers in related fields to select appropriate animal models.
作者
武上雯
李桓
龚晓红
陆超群
陈一鸣
邢清桦
李松伟
WU Shangwen;LI Huan;GONG Xiaohong;LU Chaoqun;CHEN Yiming;XING Qinghua;LI Songwei(the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China.;Henan University of Chinese Medicine,Zhengzhou 450046.;Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou 450000)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2023年第8期1051-1060,共10页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金面上项目(81874465)
国家中医临床研究基地科研专项(2021JDZX2012)
河南省科技攻关项目(222102310392)。
关键词
结缔组织病相关肺间质病变
动物模型
模型构建
CTD-ILD
animal models
model building Conflicts of Interest:The authors declare no conflict of interest.
