摘要
目的:分析单纯性肥胖女性胰岛素抵抗、性激素水平紊乱情况及并发多囊卵巢综合征(PCOS)的影响因素。方法:选取2020年8月至2022年8月在该院就诊的184例单纯性肥胖女性患者为研究对象,根据是否发生PCOS将其分为发生组和未发生组,比较两组基础资料、胰岛素抵抗指标及性激素水平,并采用多因素Logistic回归分析单纯性肥胖女性患者发生PCOS的影响因素。结果:184例单纯性肥胖女性患者发生PCOS 67例(36.41%),未发生117例(63.59%);发生组和未发生组患者年龄、孕次、产次及合并高血压、高脂血症、糖尿病情况比较,差异均无统计学意义(P>0.05);两组体质量指数(BMI)、PCOS家族史、月经周期紊乱及合并抑郁、焦虑、失眠、维生素D缺乏症情况比较,差异均有统计学意义(P<0.05);发生组胰岛素抵抗指数(HOMA-IR)及血清黄体生成素(LH)、睾酮水平均高于未发生组,胰岛素敏感性指数及卵泡刺激素(FSH)水平均低于对照组,差异有统计学意义(P<0.05);多因素Logistic回归分析结果显示,合并维生素D缺乏症,BMI、HOMA-IR、LH、睾酮水平升高,以及FSH水平降低均为单纯性肥胖女性并发PCOS的危险因素(OR>1,P<0.05)。结论:合并维生素D缺乏症,BMI、HOMA-IR、LH、睾酮水平升高,FSH水平降低均为单纯性肥胖女性并发PCOS的危险因素,临床可针对这些因素予以干预,以降低PCOS发生风险。
Objective:To analyze insulin resistance and sex hormone disturbance conditions and influencing factors of polycystic ovary syndrome(PCOS)in women with simple obesity.Methods:184 female patients with simple obesity who were treated in the hospital from August 2020 to August 2022 were selected as the research objects.According to the occurrence of PCOS,these patients were divided into the occurrence group and the non-occurrence group.The basic data as well as the insulin resistance index and sex hormone levels were compared between the two groups.The influencing factors of PCOS in the patients with simple obesity were analyzed using multivariate logistic regression analysis.Results:There were 67 cases(36.41%)of PCOS in the 184 patients with simple obesity,and 117 cases(63.59%)were not suffered from.There were no significant differences in age,gravidity,parity,combined hypertension,combined hyperlipidemia and combined diabetes between the occurrence group and the non-occurrence group(P>0.05).There were significant differences in body mass index(BMI),family history of PCOS,menstrual cycle disturbance,combined depression,combined anxiety,insomnia and vitamin D deficiency between the two groups(P<0.05).The insulin resistance index(HOMAIR)and the serum luteinizing hormone(LH)and testosterone levels in the occurrence group were higher than those in the non-occurrence group,the insulin sensitivity index and the follicle stimulating hormone(FSH)levels were lower than those in the control group,and the differences were statistically significant(P<0.05).Multivariate logistic regression analysis showed that combined vitamin D deficiency,increased BMI,HOMA-IR,LH and testosterone levels,and decreased FSH level were the risk factors for PCOS in the simple obese women(P<0.05).Conclusions:Combined vitamin D deficiency,increased BMI,HOMA-IR,LH and testosterone levels,and decreased FSH levels are the risk factors for PCOS in the simple obese women.Clinically,these factors can be intervened to reduce the risk of PCOS.
作者
李亚彩
LI Yacai(Department of Endocrinology of General Hospital of Pingdingshan Shenma Medical Group,Pingdingshan 467000 Henan,China)
出处
《中国民康医学》
2023年第17期26-28,35,共4页
Medical Journal of Chinese People’s Health
关键词
单纯性肥胖
胰岛素抵抗
性激素
多囊卵巢综合征
影响因素
Simple obesity
Insulin resistance
Sex hormone
Polycystic ovary syndrome
Influencing factor
