摘要
目的 探讨外周血微小RNA-21(miR-21)、转化生长因子-β1(TGF-β1)在非小细胞肺癌(NSCLC)临床诊断及化疗疗效评估中的价值。方法 回顾性分析2020年1月-2022年1月收治的73例NSCLC患者的临床资料,另选取50例体检健康者为对照组,检测并比较两组受检者外周血miR-21、TGF-β1水平,采用受试者工作特征曲线(ROC)分析miR-21、TGF-β1对NSCLC的临床诊断价值。所有NSCLC患者均接受GP方案(顺铂+吉西他滨)化疗,治疗2个周期后再次检测外周血miR-21、TGF-β1水平,评估化疗疗效;根据疗效分为有效组(47例)和无效组(26例),比较不同疗效亚组患者外周血miR-21、TGF-β1水平,采用ROC曲线分析miR-21、TGF-β1对NSCLC患者化疗疗效的评估价值。结果 NSCLC组患者外周血miR-21、TGF-β1水平均明显高于对照组受检者,差异有统计学意义(P<0.05)。ROC曲线显示,miR-21、TGF-β1对NSCLC具有一定临床诊断价值(AUC=0.848、0.863,P<0.01),且两者联合(AUC=0.931,P<0.01)诊断价值高于单独诊断价值。有效组患者外周血miR-21、TGF-β1水平均明显低于无效组患者,差异有统计学意义(P<0.05)。ROC曲线显示,miR-21、TGF-β1对NSCLC患者化疗疗效具有一定评估价值(AUC=0.882、0.795,P<0.01),且两者联合(AUC=0.934,P<0.01)评估价值更高。结论 miR-21、TGF-β1在NSCLC患者外周血中水平异常升高,联合检测外周血miR-21、TGF-β1水平对NSCLC临床诊断及化疗疗效评估具有较高应用价值。
Objective To investigate the value of peripheral blood microRNA-21(miR-21)and transforming growth factor-β1(TGF-β1)in the clinical diagnosis of non-small cell lung cancer(NSCLC)and the evaluation of chemotherapy efficacy.MethodsThe clinical data of 73 NSCLC patients admitted from January 2020 to January 2022 were retrospectively analyzed,and 50 healthy subjects were selected as the control group,and the peripheral blood miR-21 and TGF-β1 of the two groups of subjects were detected and compared.Receiver operating character-istic curve(ROC)was used to analyze the clinical diagnostic value of miR-21 and TGF-β1 in NSCLC.All NSCLC patients received GP regimen(cisplatin+gemcitabine)chemotherapy.After 2 cycles of treatment,the levels of miR-21 and TCF-β1 in peripheral blood were detected again.The efficacy of chemotherapy was evaluated and di-vided into an effective group(47 cases)and an ineffective group(26 cases)according to the curative effect.The lev-els of miR-21 and TCF-β1 in peripheral blood of patients with different efficacy subgroups were compared,and the ROC curve was used to analyze the evaluation value of miR-21 and TGF-β1 on the efficacy of chemotherapy in pa-tients with NSCLC.ResultsThe levels of miR-21 and TCF-β1 in peripheral blood of patients in NSCLC group were significantly higher than those in control group,and the difference was statistically significant(P<0.05).The ROC curve showed that miR-21 and TGF-β1 had certain clinical diagnostic value for NSCLC(AUC=0.848,0.863,P<0.01),and the combination of the two(AUC=0.931,P<0.01)had higher clinical diagnostic value.The levels of peripheral blood miR-21 and TGF-β1 in the effective group were significantly lower than those in the ineffective group,with statistical differences(P<0.05).The ROC curve showed that miR-21 and TGF-β1 had a certain evaluation value for the efficacy of chemotherapy in NSCLC patients(AUC=0.882,0.795,P<0.01),and the combination of the two(AUC=0.934,P<0.01)had a higher evaluation value.Conclusion The levels of miR-21 and TG
作者
韦健健
韩丽丽
郭明珠
杨贤
庞晶
WEI Jian-jian;HAN Li-li;GUO Ming-zhu;YANG Xian;PANG Jing(Respiratory Medicine,Zhoukou Central Hospital,Zhoukou,Henan 466000,China)
出处
《医药论坛杂志》
2023年第15期55-59,共5页
Journal of Medical Forum
