摘要
胃癌(gastric cancer,GC)是一种危害人类健康和生命的严重恶性肿瘤。Twist基因在促进肿瘤形成方面发挥着重要作用,主要通过调控基因表达和上皮-间充质转化(epithelial-mesenchymal transition,EMT)。Twist在胃癌中促进了EMT的发生,但对于Twist及其调控因子在EMT发生机制以及Twist引发的EMT在肿瘤转移中的作用机制尚未完全明确。本文旨在介绍Twist基因及其调控因子在胃癌进展中的作用,回顾相关研究进展,并提出发展方向预测。通过深入分析和探讨,本文将为进一步理解胃癌的发生机制和开展有效的治疗策略提供有益的指导和建议。
Gastric cancer(GC)is a severe malignant tumor that poses a significant threat to human health and life.Recent studies have revealed the crucial role of the Twist gene in promoting tumor formation,primarily through the regulation of gene expression and epithelial-mesenchymal transition(EMT).Previous research has demonstrated that Twist promoted EMT occurrence in gastric cancer.However,the mechanisms underlying Twist and its regulatory factors in EMT initiation,as well as the role of Twist-induced EMT in tumor metastasis,remain incompletely understood.This paper aims to comprehensively present the role of the Twist gene and its regulatory factors in the progression of gastric cancer,reviewing relevant research advances and providing unique academic perspectives and predicted development directions.Through in-depth analysis and exploration,this paper will offer valuable guidance and suggestions for further understanding the mechanisms of gastric cancer occurrence and the development of effective therapeutic strategies,while adhering to the language characteristics of scientific papers.
作者
于淇
段全红
张庭
徐万鹏
YU Qi;DUAN Quanhong;ZHANG Ting;XU Wanpeng(School of Clinical Medicine,Weifang Medical University,Weifang 261000,China;Affiliated Hospital of Wanfang Medical University,School of Clinical Medicine,Weifang 261000,China)
出处
《生命的化学》
CAS
2023年第8期1252-1259,共8页
Chemistry of Life
基金
山东省医药卫生科技发展计划项目(202104010652)。
