摘要
目的 探讨三氧化二砷经导管动脉栓塞化疗对原发性肝癌患者的治疗效果。方法 根据治疗方式的不同将210例原发性肝癌患者分为对照组(n=105)和观察组(n=105),对照组患者予以氟尿苷+奥沙利铂+吡柔比星经导管动脉栓塞化疗,观察组患者予以氟尿苷+奥沙利铂+三氧化二砷经导管动脉栓塞化疗。比较两组患者的临床疗效、血清肿瘤标志物[脆性组氨酸三联体(FHIT)、p16蛋白]水平及不良反应发生情况。结果 观察组患者的总有效率明显高于对照组,差异有统计学意义(P﹤0.01)。治疗后,两组患者血清FHIT、p16蛋白水平均高于本组治疗前,观察组患者血清FHIT、p16蛋白水平均高于对照组,差异均有统计学意义(P﹤0.05)。观察组患者心电图T波及ST-T改变、胆红素异常、白蛋白减少、天冬氨酸转氨酶(AST)升高、丙氨酸转氨酶(ALT)升高发生率均明显低于对照组,差异均有统计学意义(P﹤0.01)。结论 三氧化二砷经导管动脉栓塞化疗能够提高原发性肝癌患者的临床疗效,改善肿瘤标志物水平,降低不良反应发生率。
Objective To investigate the therapeutic effect of transcatheter arterial chemoembolization with arsenic trioxide in patients with primary liver cancer.Method A total of 210 patients with primary liver cancer were divided in-to control group(n=105,transcatheter arterial chemoembolization with floxuridine+oxaliplatin+pirarubicin)and observa-tion group(n=105,transcatheter arterial chemoembolization with floxuridine+oxaliplatin+arsenic trioxide)according to different treatment methods.The clinical efficacy,serum tumor markers[fragile histidine triad(FHIT),p16 protein]levels and adverse reactions were compared between the two groups.Result The total effective rate of the observation group was higher than that of the control group(P<0.01).After treatment,the serum FHIT and p16 protein of the two groups were higher than those before treatment,with higher levels in the observation group than those in the control group(P<0.05).The incidence of electrocardiogram changes of T wave and ST-T,abnormal bilirubin,decreased albumin,elevated aspartate aminotransferase(AST)and alanine aminotransferase(ALT)in the observation group were significantly lower than those in the control group(P<0.01).Conclusion Transcatheter arterial chemoembolization with arsenic trioxide can improve the clinical efficacy,tumor markers of patients with primary liver cancer and reduce the adverse reactions.
作者
王朝阳
姚黎程
杨慧
WANG Zhaoyang;YAO Licheng;YANG Hui(Intervention Center,Ankang Hospital of Traditional Chinese Medicine,Ankang 725000,Shaanxi,China;Department of Hepatobiliary Surgery,Ankang Hospital of Traditional Chinese Medicine,Ankang 725000,Shaanxi,China;Department of Oncology Rehabilitation,Shaanxi Kangfu Hospital,Xi’an 710065,Shaanxi,China)
出处
《癌症进展》
2023年第14期1591-1594,共4页
Oncology Progress
关键词
原发性肝癌
经导管动脉栓塞化疗
三氧化二砷
不良反应
primary liver cancer
transcatheter arterial chemoembolization
arsenic trioxide
adverse reaction
