摘要
目的 观察对比氢溴酸山莨菪碱注射液与盐酸消旋山莨菪碱治疗肾绞痛的临床疗效与不良反应,验证氢溴酸山莨菪碱注射液对肾绞痛临床治疗的有效性与安全性。方法 选取2018-2020年在本院就诊的937例肾绞痛患者,按照随机数字表将患者随机分为对照组(n=459)与试验组(n=478),对照组采用盐酸消旋山莨菪碱注射液肌肉注射,试验组采用氢溴酸山莨菪碱注射液肌肉注射。比较两组用药后有效率、视觉模拟疼痛评分(VAS评分)、疼痛缓解与消失时间;比较两组不良反应情况进行安全性评价。结果 试验组的总有效率优于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者VAS评分,差异无统计学意义(P>0.05);用药30min、1h后VAS评分,治疗前后差异有统计学意义(P<0.05)。试验组与对照组用药后评分差异有统计学意义(P<0.05)。试验组疼痛缓解与消失时间少于对照组,差异有统计学意义(P<0.05)。对照组不良反应发生率高于试验组,差异有统计学意义(P<0.05)。结论 氢溴酸山莨菪碱可有效快速镇痛,不良反应较少,临床疗效确切。
Objective:To observe and compare clinical effect and adverse reactions of anisodamine hydrobromic acid injection and raceanisodamine hydrochloride in treatment of renal colic,verify effect and safety of anisodamine hydrobromic acid injection for renal colic.Methods The paper chose 937 patients with renal colic in our hospital from 2018 to 2020 and,divided them into control group(n=459)and experiment group(n=478)randomly according to random number table.Control group was treated with raceanisodamine hydrochloride injection Intramuscular injection,10mg/time;if pain disd not decrease after half an hour,an additional 10mg could be administered repeatedly.Experiment group was treated with anisodamine hydrobromic acid injection Intramuscular injection,10mg/time.If pain did not decrease after half an hour,an additional 10mg could be administered repeatedly.Other smooth muscle antispasmodic should be excluded in both groups.Effective rate,visual analogue pain scores(VAS scores),pain relief and disappearance time was compared between two groups after medication;adverse reactions between two groups was compared for safety evaluation.Results There was no statistically significant difference in effect between experimental group and control group(P>0.05).There was statistically significant difference in effective rate between experimental group and control group(P<0.05).After medication,the VAS index of experimental group was significantly lower than control group(P<0.05).Pain relief and disappearance time in experimental group was shorter than control group(P<0.05).Difference in incidence of adverse reactions between experimental group and control group was statistically significant(P<0.05).Conclusion Anisodamine hydrobromic acid can relieve pain effectively and rapidly,with less adverse reactions and definite clinical effect,which is worthy of further promotion.
作者
李茂生
黄飚
宋道强
LI Maosheng;HUANG Biao;SONG Daoqiang(Urology Department,Chengdu City Shuangliu District The First People's Hospital,Chengdu,Sichuan 610000;Urology Department,Chengdu City Tianfu New Area People's Hospital,Chengdu,Sichuan 610000;Chengdu City Jinniu District People's Hospital,Chengdu,Sichuan 610000)
出处
《智慧健康》
2023年第17期143-147,共5页
Smart Healthcare
关键词
氢溴酸山莨菪碱
肾绞痛
临床试验
Anisodamine hydrobromic acid
Renal colic
Clinical experiment
