摘要
目的:分析血清中性粒细胞计数与淋巴细胞计数比值(NLR)、生长分化因子–15(GDF–15)、瞬时受体电位通道1(TRPC1)与心力衰竭(HF)患者心功能指标的相关性。方法:选择2019年6月至2020年12月在新乡市第一人民医院诊治的HF患者220例作为观察组,同期选择在新乡市第一人民医院体检的健康人群220例作为对照组,检测两组研究对象血清NLR、GDF–15、TRPC1水平,并采用超声心动图检测两组对象的心功能,进行各指标的组间比较以及指标间的相关性分析。结果:观察组患者的超声左心房内径(LAD)、左心室舒张期末内径(LVEDD)都显著高于对照组,左心室射血分数(LVEF)显著低于对照组,差异均具有统计学意义(P<0.05)。观察组患者的血清NLR、GDF–15及TRPC1水平都显著高于对照组,差异均具有统计学意义(P<0.05)。在观察组中,Pearson相关性分析结果显示,血清NLR、GDF–15、TRPC1与LAD、LVEDD均呈正相关(P<0.05),与LVEF均呈负相关(P<0.05)。结论:HF患者多伴随有血清NLR、GDF–15及TRPC1的水平升高,并且上述指标与患者的心功能指标均存在相关性。
Objective The correlation of serum neutrophils lymphocyte count ratio(NLR),growth differentiation factor-15(GDF-15),transient receptor potential channel 1(TRPC1)and cardiac function indexes in patients with heart failure(HF)was analyzed.Methods A total of 220 HF patients treated in Xinxiang First People's Hospital from June 2019 to December 2020 were selected as an observation group,and 220 healthy people who were examined in Xinxiang First People's Hospital during the same period were selected as a control group.Serum NLR,GDF-15 and TRPC1 levels of the two groups of subjects were detected.Echocardiography was used to detect the cardiac function of the two groups,and the inter-group comparison and correlation analysis of each index were performed.Results The ultrasonic left atrial diameter(LAD)and left ventricular end-diastolic diameter(LVEDD)in the observation group were higher than those in the control group,and the left ventricular ejection fraction(LVEF)was lower than that in the control group,the differences were statistically significant(P<0.05).The levels of serum NLR,GDF-15 and TRPC1 in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).In the observation group,Pearson correlation analysis showed that serum NLR,GDF-15 and TRPC1 were positively correlated with LAD and LVEDD(P<0.05),and negatively correlated with LVEF(P<0.05).Conclusion HF patients were often accompanied by elevated levels of serum NLR,GDF-15 and TRPC1,and the above indicators were correlated with the cardiac function indicators of patients.
作者
王会珍
葛廷
孙伟敬
WANG Huizhen;GE Ting;SUN Weijing(Xinxiang First People's Hospital,Henan Xinxiang 453000;Xinxiang Municipal Government Hospital,Henan Xinxiang 453000)
出处
《深圳中西医结合杂志》
2023年第14期54-57,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
