摘要
目的:比较不同血管通路对血液透析患者疗效、炎性因子水平的影响。方法:选取2019年8月至2022年8月道真仡佬族苗族自治县人民医院收治的80例血液透析患者作为研究对象。根据血管通路的不同将其分为对照组(40例)和研究组(40例),对照组给予深静脉置管,研究组给予动静脉人工血管内瘘术。比较两组患者的透析疗效、肾功能、炎症因子水平以及并发症发生情况。结果:建立通路后,两组患者的尿素清除率、尿素清除指数均高于建立通路前,且研究组高于对照组,差异具有统计学意义(P<0.05)。建立通路后,两组患者的血尿素氮、血肌酐水平均降低,且研究组低于对照组,差异具有统计学意义(P<0.05)。建立通路后,对照组的hs-CRP、TNF-α、IL-6水平均较建立通路前升高,差异具有统计学意义(P<0.05);研究组的hs-CRP、TNF-α、IL-6水平与建立通路前比较差异无统计学意义(P>0.05);研究组的hs-CRP、TNF-α、IL-6水平均低于对照组,差异具有统计学意义(P<0.05)。研究组的并发症发生率(7.5%)低于对照组(27.5%),差异有统计学意义(P<0.05)。结论:与深静脉置管相比,动静脉人工血管内瘘血管通路能够提高临床疗效,减轻相关炎症反应,改善肾功能,减少并发症,安全性较好。
Objective:To compare the effects of different vascular pathways on the therapeutic effect and the level of inflammatory factors in hemodialysis patients.Methods:A total of 80 hemodialysis patients admitted to the People’s Hospital of Daozhen Gelao Nationality and Miao Nationality Autonomous County from August 2019 to August 2022 were selected as the study objects.According to the different vascular access,the patients were divided into control group(40 cases)and study group(40 cases).The control group was given deep vein catheterization,and the study group was given arteriovenous artificial vascular fistula.The effects of dialysis,renal function,inflammatory factors and complications were compared between the two groups.Results:After the establishment of the pathway,the urea clearance rate and urea clearance index of 2 groups were higher than before the establishment of the pathway,and the study group was higher than the control group,the difference was statistically significant(P<0.05).After the establishment of access,the blood urea nitrogen and blood creatinine levels of 2 groups were decreased,and the study group was lower than the control group,the difference was statistically significant(P<0.05).After the establishment of the pathway,the levels of hs-CRP,TNF-α and IL-6 in the control group were higher than those before the establishment of the pathway,and the differences were statistically significant(P<0.05).The levels of hs-CRP,TNF-α and IL-6 in the study group were not significantly different from those before the establishment of the pathway(P>0.05).The levels of hs-CRP,TNF-α and IL-6 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The complication rate of the study group(7.5%)was lower than that of the control group(27.5%),and the difference was statistically significant(P<0.05).Conclusion:Compared with deep vein catheterization,arteriovenous artificial vascular fistula vascular access can improve clinical efficacy,reduce rel
作者
韩进
HAN Jin(People’s Hospital of Daozhen Mulao and Miao Autonomous County,Zunyi City,Guizhou Province,Daozhen Guizhou 563500)
关键词
血液透析
血管通路
炎症反应
动静脉人工血管内瘘
hemodialysis
Vascular access
Inflammatory response
Arterio venous artificial vascular fistula
