摘要
目的探讨硬性高透气性角膜接触镜(RGP)对圆锥角膜患者角膜光密度的影响。方法选取2020年1月至6月于甘肃省人民医院眼视光学中心就诊的圆锥角膜患者45例(45眼)作为研究对象。根据Amsler-Krumeich圆锥角膜分级方法对患者进行分级和分组。45例圆锥角膜患者中轻度(Ⅰ级)组15例(15眼)、中度(Ⅱ级)组15例(15眼)、重度(Ⅲ/Ⅳ级)组15例(15眼)。三组患者戴镜前及戴镜后3个月、6个月和12个月行常规视力、裂隙灯检查。采用Pentacam三维眼前节分析系统检测患者角膜最大曲率(K m)、最薄点角膜厚度(TCT)、角膜后表面高度(PCE)以及角膜光密度。角膜光密度主要分析角膜12 mm直径范围内的数值,以角膜顶点为中心,分别测量0~2 mm、>2~6 mm、>6~12 mm和整体0~12 mm范围内的角膜光密度。并根据角膜厚度将角膜分为3层,记录角膜前层(120μm)、后层(60μm)、中层(前后层之间厚度)和全层的角膜光密度。对比三组患者戴镜前后角膜光密度的差异,分析其变化与K m、TCT、PCE的相关性。结果戴镜前三组患者之间K m、TCT和PCE差异均有统计学意义(均为P<0.05),中度组和重度组患者K m和PCE大于轻度组,TCT小于轻度组(均为P<0.05)。轻度组和中度组圆锥角膜患者不同直径范围内前层、中层、后层和全层的角膜光密度在戴镜后与戴镜前相比差异均无统计学意义(均为P>0.05)。重度组圆锥角膜患者在戴镜后6个月0~2 mm、>2~6 mm直径范围内前层、中层和全层角膜光密度较戴镜前有升高的趋势,但差异均无统计学意义(均为P>0.05)。圆锥角膜患者0~2 mm前层角膜光密度变化(戴镜后12个月与戴镜前的差值)与戴镜前K m呈正相关(r=0.405,P=0.03)。0~2 mm、>2~6 mm前层角膜光密度变化与戴镜前PCE呈正相关(r=0.323,P=0.02;r=0.203,P=0.01)。0~2 mm、>2~6 mm前层角膜光密度变化与戴镜前TCT呈负相关(r=-0.168,P=0.03;r=-0.207,P=0.04)。其余不同深度直径范围内�
Objective To investigate the effects of rigid gas permeable(RGP)contact lenses on corneal densitometry(CD)in patients with keratoconus.Methods Forty-five patients(45 eyes)with keratoconus who received treatment in the Optometry Center of Gansu Provincial People’s Hospital from January to June 2020 were selected.According to the Amsler-Krumeich classification of keratoconus,the patients were divided into the mild(grade I)group(15 patients with 15 eyes),moderate(gradeⅡ)group(15 patients with 15 eyes)and severe(gradeⅢ/Ⅳ)group(15 patients with 15 eyes).All patients underwent visual acuity and slit lamp examinations before and 3,6,and 12 months after wearing RGP lenses.The maximum corneal curvature(K m),the thinnest corneal thickness(TCT),the posterior corneal elevation(PCE),and the CD were obtained by Pentacam.CD was measured in the 0-2 mm,>2-6 mm,>6-12 mm and 0-12 mm diameter ranges,respectively,with the corneal apex at the center.The cornea was divided into 3 layers according to the thickness.CD values were recorded in the anterior(120μm),central(between the anterior and posterior layers),posterior(60μm)and whole layers.The difference in CD before and after wearing the RGP lenses was compared among the three groups,and the correlations between CD and K m,TCT,PCE were analyzed.Results Before wearing the RGP lenses,there were statistically significant differences in K m,TCT and PCE among the three groups(all P<0.05).K m and PCE in the moderate and severe groups were greater than those in the mild group,while TCT was smaller than that in the mild group(all P<0.05).No statistical differences were found in the mild and moderate groups in CD in the anterior,central,posterior and whole layers in different diameter ranges after wearing the RGP lenses compared with those before wearing the RGP lenses(all P>0.05).The severe group showed a mild CD increase in the anterior,central and whole layers in the 0-2 mm and>2-6 mm diameter ranges 6 months after wearing the RGP lenses,but the differences were not statistically
作者
杨丽媛
杨君
YANG Liyuan;YANG Jun(Department of Optometry,Gansu Provincial Hospital,Lanzhou 300070,Gansu Province,China)
出处
《眼科新进展》
CAS
北大核心
2023年第10期786-789,共4页
Recent Advances in Ophthalmology
基金
甘肃省自然科学基金项目(编号:17JR5RA039)
兰州市科技计划项目(编号:2022-5-58)。
