摘要
目的:比较单用左氧氟沙星和左氧氟沙星联合头孢呋辛在治疗18~59岁非重症社区获得性肺炎(CAP)住院患者中的临床疗效。方法:选择2018年1月—2021年12月收治的18~59岁非重症CAP患者290例,根据不同的治疗方案分为单用左氧氟沙星组(A组,143例)和左氧氟沙星联合头孢呋辛组(B组,147例),采用双向性队列研究方法,比较两组患者治疗后的临床疗效。多因素Logistic回归分析评估住院时间、入院前抗菌药物使用、体温、白细胞计数、相关感染指标等对结局的影响;采用SPSS 25.0软件进行统计分析。结果:A组的总有效率为90.2%,B组总有效率为87.1%,两组比较差异无统计学意义(P>0.05);多因素Logistic回归分析显示影响疗效的独立危险因素为入院时的白细胞计数水平和住院时间(P<0.05)。结论:左氧氟沙星单用与左氧氟沙星联合头孢呋辛治疗18~59岁非重症CAP的临床疗效相似;白细胞计数水平和住院时间是影响18~59岁非重症CAP患者疗效的独立危险因素;对于白细胞计数较高的患者,应该更加积极治疗,同时,住院时间过长会增加院内感染的风险,应及时采取相应的预防和控制措施。
Objective:To compare the clinical efficacy of levofloxacin alone and levofloxacin combined with cefuroxime in treating non-severe community-acquired pneumonia(CAP)in patients aged 18~59 years.Methods:A total of 290 patients aged 18~59 years with non-severe CAP admitted from January 2018 to December 2021 were selected and divided into levofloxacin alone group(143 cases)and levofloxacin combined with cefuroxime group(147 patients)according to the different treatment drugs.A two-way cohort study method was used.The clinical efficacy after treatment was compared between the two groups.Multivariate Logistic regression analysis was used to evaluate the effects of length of hospital stay,use of antibiotics before admission,body temperature,white blood cell count in blood routine,and related infection indicators on the results.SPSS 25 software was used for statistical analysis.Results:The effective rate of the levofloxacin group was 90.2%,and the effective rate of levofloxacin combined with the cefuroxime group was 87.1%.The two groups had no significant difference(P>0.05).Multivariate Logistic regression analysis showed that the independent risk factors affecting the efficacy were white blood cell count at admission(P<0.05)and length of hospital stay(P<0.05).Conclusion:There was no significant difference in clinical efficacy between levofloxacin alone and cefuroxime combined in treating non-severe CAP aged 18~59 years.White blood cell count and length of hospital stay are independent risk factors affecting the efficacy of non-severe CAP patients aged 18~59 years.Treatment should be more active for patients with high white blood cell counts.At the same time,too long a hospital stay will increase the risk of nosocomial infection,and corresponding prevention and control measures should be taken in time.
作者
张曙光
姚楷楠
邱绿琴
梁奇
ZHANG Shuguang;YAO Kainan;QIU Lyuqin;LIANG Qi(The Bao'an District Hospital of Traditional Chinese Medicine,Shenzhen 518133,China)
出处
《临床医药实践》
2023年第10期726-729,共4页
Proceeding of Clinical Medicine
基金
深圳市宝安区基础研究(医疗卫生类)项目(项目编号:2021JD112)。
