摘要
目的分析在为甲状腺功能亢进症(简称:甲亢)患者实施治疗的过程中,丙硫氧嘧啶与甲疏咪唑对肝功能的影响。方法选取2019年7月—2020年7月天津医科大学朱宪彝纪念医院收治的甲亢患者78例,按照随机1∶1分组原则将患者分为甲疏咪唑组和丙硫氧嘧啶组,每组各39例。甲疏咪唑组患者应用甲疏咪唑治疗,丙硫氧嘧啶组患者应用丙硫氧嘧啶治疗。对比两组肝损伤发生率、治疗后的相关肝功能指标升高率以及肝损伤发生时间。结果甲疏咪唑组肝损伤发生率为7.69%,低于丙硫氧嘧啶组的30.77%,差异有统计学意义(χ^(2)=9.545,P<0.05)。甲疏咪唑组TBiL、AST、ALT以及ALP升高率分别为2.56%、0.00%、5.13%、2.56%,均低于丙硫氧嘧啶组的10.26%、7.69%、20.51%、10.26%,差异均有统计学意义(P<0.05)。甲疏咪唑组肝损伤发生时间为(18.23±1.56)d,短于丙硫氧嘧啶组的(31.59±2.14)d,差异有统计学意义(P<0.05)。结论相较于丙硫氧嘧啶,甲疏咪唑所导致甲亢患者肝功能损伤的发生概率更低且程度更为轻微,各项肝功能指标升高情况较为少见,肝损伤时间相对较短,值得临床推广应用。
Objective To analyze the effects of propylthiouracil and thiamazole on liver function in the progress of treatment for patients with hyperthyroidism.Methods A total of 78 hyperthyroidism patients admitted to Tianjin Medical University Chu Hsien-I Memorial Hospital from July 2019 to July 2020 were selected and divided into thiamazole group and propylthiouracil group according to the principle of random 1∶1 grouping,with 39 patients in each group.Patients in thiamazole group were treated with thiamazole,and patients in propylthiouracil group were treated with propylthiouracil.The incidence of liver injury,the increase rate of related liver function indicators after treatment,and the occurrence time of liver injury between the two groups were compared.Results The incidence of liver injury in thiamazole group was 7.69%,which was lower than 30.79%in propylthiouracil group,and the difference was statistically significant(χ^(2)=9.545,P<0.05).The increase rates of TBiL,AST,ALT and ALP in thiamazole group were 2.56%,0.00%,5.13%and 2.56%,respectively,which were lower than those in propylthiouracil group with 10.26%,7.69%,20.51%and 10.26%,and the differences were statistically significant(P<0.05).The occurrence time of liver injury in thiamazole group was(18.23±1.56)days,which was shorter than that in propylthiouracil group with(31.59±2.14)days,and the difference was statistically significant(P<0.05).Conclusion Compared with propylthiouracil,the incidence of liver function injury in hyperthyroidism patients caused by thiamazole was lower and the degree was more slight,the increase of various liver function indicators were relatively rare,and the time of liver injury was relatively short,which was worthy of clinical promotion and application.
作者
郭庆霞
GUO Qing-xia(Pharmacy Department,Tianjin Medical University Chu Hsien-I Memorial Hospital,Tianjin Institute of Endocrinology,Key Laboratory of Hormone and Development of National Health Commission,Tianjin Key Laboratory of Metabolic Diseases,Tianjin 300134,China)
出处
《中国城乡企业卫生》
2023年第8期6-8,共3页
Chinese Journal of Urban and Rural Enterprise Hygiene
