摘要
抑郁症是常见的精神类疾病,临床表现为情绪低落、精神运动迟缓、动力减弱、快感缺失、绝望甚至自杀。抑郁症患者临床表现的异质化表明其发病机制具有多样性。蛋白水平及基因异常是抑郁症发病的一个重要因素。文中聚焦抑郁症相关蛋白的水平及其调控基因,进一步阐述抑郁症的发病机制,并提出目前抑郁症研究领域存在的问题和挑战,为开发新型抗抑郁药物提供理论基础。
Depression is a common psychiatric disorder characterized by a wide range of clinical manifestations,including depressed mood,psychomotor retardation,diminished motivation,anhedonia,despair,and even suicidality.The heterogeneity of the features of depression indicates the diversity of its pathogenesis.Protein levels and their genetic abnormalities are essential factors in the pathogenesis of depression.This review focuses on the levels and genetic abnormalities of depression-related proteins to further elaborate the pathogenesis of depression and presents current problems and challenges to provide a theoretical foundation for the development of novel antidepressant medications.
作者
王惠芹
陈乃宏
Wang Huiqin;Chen Naihong(College of Pharmacy,Hunan University of Chinese Medicine,Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces,Changsha 410208,China;Neuroscience Center,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2023年第9期1078-1083,共6页
Chinese Journal of Neurology
基金
国家自然科学基金(82130109)
中国医学科学院科技创新工程项目(2021-I2M-1-020)。
关键词
抑郁症
蛋白质
基因
发病机制
Depressive disorder
Protein
Gene
Pathogenesis
