摘要
目的探讨富马酸喹硫平联合丙戊酸钠治疗双相障碍躁狂症患者的治疗价值。方法选取2018年4月至2021年3月抚州市第三医院收治的84例双相障碍躁狂症患者作为研究对象,按照治疗方式不同分为对照组与观察组,每组42例。对照组给予单纯富马酸喹硫平治疗,观察组在对照组治疗基础上给予丙戊酸钠治疗,比较两组治疗前后心理情况[焦虑自评量表(SAS)和抑郁自评量表(SDS)]、狂躁症状[贝壳拉范森躁狂量表(BPRS)]、生命质量、不良反应发生情况。结果治疗前,两组SAS、SDS评分比较差异无统计学意义;治疗后,两组SAS、SDS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组BPRS评分比较差异无统计学意义;治疗后,两组BPRS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组角色受限、躯体疼痛、生命活力、感情因素、社交能力、精神健康、总体健康、活动能力评分比较差异无统计学意义;治疗后,两组角色受限、躯体疼痛、生命活力、感情因素、社交能力、精神健康、总体健康、活动能力评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率为7.14%,低于对照组的26.19%,差异有统计学意义(P<0.05)。结论富马酸喹硫平联合丙戊酸钠治疗双相障碍躁狂症患者疗效确切,可显著改善患者狂躁症状改,缓解患者内心焦虑情绪及抑郁情绪,改善患者生命质量,降低不良反应事件发生率。
Objective To investigate the therapeutic value of quetiapine fumarate combined with sodium valproate in the treatment of bipolar disorder mania.Methods A total of 84 patients with bipolar mania treated in Fuzhou Third Hospital from April 2018 to March 2021 were selected as the reseach subjects,and they were divided into the control group and the observation group according to different treatment methods,with 42 cases in each group.The control group was treated with quetiapine fumarate alone,and the observation group was treated with sodium valproate on the basis of the control group,the psychological improvement(self-rating anxiety scale[SAS]and self-rating depression scale[SDS]),the improvement of mania symptoms(Bech-Rafaelsen Mania rating scale,BPRS),quality of life before and after treatment and the occurrence of adverse reactions were compared between the two groups.Results Before treatment,there were no significant differences in SAS and SDS scores between the two groups;after treatment,SAS and SDS scores of the two groups were lower than those before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in BPRS score between the two groups;after treatment,BPRS scores of the two groups were lower than those before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the scores of role limitation,physical pain,vital vitality,emotional factors,social ability,mental health,general health and activity ability between the two groups;after treatment,the scores of role limitation,physical pain,vital vitality,emotional factors,social ability,mental health,general health and activity ability of the two groups were higher than those before treatment,and the observation group was higher than the control group,the differences were statistically significant(P<0.05).The tota
作者
肖国华
魏冬冬
管锦秀
XIAO Guohua;WEI Dongdong;GUAN Jinxiu(Department of Psychiatric,Fuzhou Third Hospital,Fuzhou,Jiangxi,344000,China)
出处
《当代医学》
2023年第11期63-66,共4页
Contemporary Medicine
关键词
双相障碍躁狂症
联合治疗
富马酸喹硫平
丙戊酸钠
Bipolar disorder mania
Combination therapy
Quetiapine fumarate
Sodium valproate
