摘要
目的 探讨高剂量雌孕激素序贯联合球囊导尿管放置治疗宫腔镜术后宫腔粘连患者的临床疗效。方法 选取自2020年5月至2022年7月于成都市新都区妇幼保健院行宫腔镜手术治疗的86例宫腔粘连患者为研究对象。依据治疗手段的不同将患者分为A组(n=46)与B组(n=40)。A组采用低剂量雌孕激素序贯联合球囊导尿管放置治疗。B组采用高剂量雌孕激素序贯联合球囊导尿管放置治疗。比较两组患者的临床疗效、美国生殖协会标准(AFS)评分、术后子宫内膜厚度、宫腔再粘连发生率,以及预后情况。结果 A组治疗总有效率为78.26%(36/46),低于B组的95.00%(38/40),两组比较,差异有统计学意义(P<0.05)。B组术后美国生殖协会标准评分中的粘连范围评分、粘连类型评分、月经模式评分均低于A组,两组比较,差异均有统计学意义(P<0.05)。两组术后子宫内膜厚度均增加,且B组高于A组,差异有统计学意义(P<0.05)。B组术后宫腔再粘连发生率为2.50%(1/40),低于A组的15.22%(7/46),两组比较,差异有统计学意义(P<0.05)。B组术后6个月健康调查简表评分高于A组,两组比较,差异有统计学意义(P<0.05)。结论 高剂量雌孕激素序贯联合球囊导尿管放置对宫腔镜术后宫腔粘连患者的疗效更佳,可较好地预防宫腔镜术后宫腔粘连,促进子宫内膜生长,恢复宫腔形态,且可改善患者的预后。
Objective To investigate the clinical effect of high dose oestrogesterone sequential combined with balloon catheter place-ment in the treatment of patients with intrauterine adhesions after hysteroscopy.Methods A total of 86 patients with uterine adhesio-sis who underwent hysteroscopic surgery in Chengdu Xindu District Maternal and Child Health Hospital from May 2020 to July 2022 were selected as the study objects.The patients were divided into group A(n=46)and group B(n=40)according to different treat-ment methods.Group A was treated with a low dose of estrogen sequentially combined with balloon catheter placement.Group B was treated with high-dose estrin sequentially combined with balloon catheter placement.The clinical efficacy,American Reproductive Soci-ety standard(AFS)score,postoperative endometrial thickness,incidence of uterine readhesion,and prognosis were compared between the two groups.Results The total effective rate of group A was 78.26%(36/46),which was lower than that of group B(95.00%,38/40),and the difference was statistically significant between the two groups(P<0.05).AFS scores,adhesion type and menstrual pattern of adhesion range in group B were lower than those in group A,and the differences between the two groups were statistically sig-nificant(P<0.05).Endometrial thickness increased in both groups,and group B was higher than group A,the difference was statisti-cally significant(P<0.05).The incidence of intrauterine readhesion in group B was 2.50%(1/40),which was lower than that in group A(15.22%,7/46),and the difference was statistically significant(P<0.05).The SF-36 score of group B was higher than that of group A six months after operation,and the difference was statistically significant between the two groups(P<0.05).Conclusion High-dose estrogen sequential combined with balloon catheter placement is more effective in patients with post-hystero-scopic uterine adhesions,which not only can better prevent post-hysteroscopic uterine adhesions,but also can significantly promote en-dometrial g
作者
周丽
黄平
黄勤华
钟茜
蒲莉
丁洪会
ZHOU Li;HUANG Ping;HUANG Qin-hua;ZHONG Qian;PU Li;DING Hong-hui(Department of Obstetrics and Gynecology,Chengdu Xindu District Maternal and Child Health Hospital,Chengdu 610599,China;Department of Reproductive Endocrinology,Second Affiliated Hospital of West China,Chengdu 610000,China)
出处
《临床军医杂志》
CAS
2023年第8期807-809,813,共4页
Clinical Journal of Medical Officers
基金
四川省自然科学基金资助项目(2022NSFSC0789)。
关键词
高剂量雌孕激素序贯治疗
球囊导尿管放置
宫腔镜
宫腔粘连
疗效
High-dose estrogen sequential therapy
Balloon catheter placement
Hysteroscopy
Intrauterine adhesion
Efficacy
