摘要
目的:观察骨肉瘤组织中卵巢肿瘤含域蛋白酶-2(YOD1)和胶质细胞系源性神经营养因子受体1(GFRA1)表达情况,并探讨二者表达与病理特征及预后的关系。方法:收集2021年2月至2022年2月130例骨肉瘤患者骨肉瘤组织标本和瘤旁组织(距离肿瘤边缘大于5 cm)标本及临床资料,根据患者1年内死亡情况分为死亡组(40例)和生存组(90例)。采用免疫组织化学法检测组织YOD1和GFRA1表达水平,多因素Cox回归分析骨肉瘤患者预后的影响因素。结果:与瘤旁组织相比,骨肉瘤组织中YOD1阳性率和GFRA1阳性率显著较高,差异有统计学意义(P<0.05)。肿瘤最大径≥3 cm、临床分期为Ⅱb~Ⅲ期、有软组织浸润、有远处转移、低分化的骨肉瘤患者YOD1阳性率和GFRA1阳性率高于肿瘤最大径<3 cm、临床分期为Ⅰ~Ⅱa期、无软组织浸润、无远处转移、中/高分化的骨肉瘤患者,差异有统计学意义(P<0.05)。与生存组相比,死亡组中YOD1阳性率和GFRA1阳性率显著较高,差异有统计学意义(P<0.05)。YOD1、GFRA1及软组织浸润是骨肉瘤患者1年内死亡的独立危险因素,差异有统计学意义(P<0.05)。结论:YOD1和GFRA1在骨肉瘤组织中高表达,且与肿瘤最大径、临床分期、软组织浸润、远处转移、分化程度及预后有关。
Objective:To observe the expressions of ovarian tumor domain-containing protease-2(YOD1)and glial cell line-derived neurotrophic factor receptor 1(GFRA1)in osteosarcoma tissues,and to explore the relationship between their expressions and pathological characteristics and prognosis.Methods:The osteosarcoma tissue specimens and paratumor tissue(more than 5 cm from the tumor edge)specimens and clinical data of 130 patients with osteosarcoma from February 2021 to February 2022 were collected,the patients were divided into death group(40 cases)and survival group(90 cases)according to the death situation within 1 year.The expression levels of YOD1 and GFRA1 in tissues were detected by immunohistochemistry,and the prognostic factors of prognosis of patients with osteosarcoma were analyzed by multivariate Cox regression analysis.Results:The positive rates of YOD1 and GFRA1 in osteosarcoma tissue were obviously higher compared with adjacent tissue(P<0.05).The positive rates of YOD1 and GFRA1 in osteosarcoma patients with tumor maximum diameter≥3 cm,clinical stage of stageⅡb-Ⅲ,soft tissue infiltration,distant metastasis,and poor differentiation were higher than those in patients with tumor maximum diameter<3 cm,clinical stage of stageⅠ-Ⅱa,no soft tissue infiltration,no distant metastasis,moderate/well differentiation(P<0.05).The positive rates of YOD1 and GFRA1 in the death group were significantly higher compared with the survival group(P<0.05).YOD1,GFRA1,and soft tissue infiltration were independent risk factors for 1-year death in patients with osteosarcoma(P<0.05).Conclusion:YOD1 and GFRA1 are highly expressed in osteosarcoma tissues,and are related to the maximum tumor diameter,clinical stage,soft tissue infiltration,distant metastasis,degree of differentiation and prognosis.
作者
郑宁宁
薛绍鸥
李娟
王海梅
姜秀贞
李书迪
胡秀茹
ZHENG Ningning;XUE Shaoou;LI Juan;WANG Haimei;JIANG Xiuzhen;LI Shudi;HU Xiuru(Department of Orthopaedics,Cangzhou Hospital of Integrated Chinese and Western medicine,Cangzhou 061000,Hebei China;Department of Nursing,Cangzhou Hospital of Integrated Chinese and Western Medicine in Hebei Province,Cangzhou 061000,Hebei China;Department of Breast Surgery,Cangzhou Hospital of Integrated Chinese and Western Medicine in Hebei Province,Cangzhou 061000,Hebei China;Department of Psychology,Cangzhou Hospital of Integrated Chinese and Western Medicine in Hebei Province,Cangzhou 061000,Hebei China;Department 1 of Radiotherapy and Chemotherapy,Cangzhou Hospital of Integrated Chinese and Western Medicine in Hebei Province,Cangzhou 061000,Hebei China)
出处
《中国中医骨伤科杂志》
CAS
2023年第8期33-37,共5页
Chinese Journal of Traditional Medical Traumatology & Orthopedics
基金
2022年度河北医学科技计划项目(20220679)。
关键词
骨肉瘤
卵巢肿瘤含域蛋白酶-2
胶质细胞系源性神经营养因子受体1
病理特征
预后
osteosarcoma
ovarian tumor domain-containing protease-2
glial cell line-derived neurotrophic factor receptor 1
pathological features
prognosis
