摘要
研究黄秋葵果胶(okra pectin,OPE)对链脲佐菌素(Streptozotocin,STZ)诱导的2型糖尿病小鼠的降血糖、降血脂作用。采用腹腔注射STZ配合高脂饲料饮食的方法诱导2型糖尿病小鼠模型。造模成功后,连续用药10 d,观测各组小鼠的饮水量、饮食量、体重、空腹血糖,检测小鼠葡萄糖耐受(Oral-glucose tolerance test,OGTT)、TC、TG、HDL、LDL、SOD、MDA等指标,观察肝脏组织形态。结果显示:与对照组相比OPE可有效调节2型糖尿病小鼠“三多一少”的典型症状,可降低糖尿病小鼠血糖水平(P<0.01),改善糖尿病小鼠体内的糖代谢异常,降低2型糖尿病小鼠血清中TC、TG、LDL-C、MDA等相关因子水平(P<0.01),升高HDL、SOD因子水平(P<0.01),修复糖尿病小鼠肝脏组织细胞形态。研究结果显示150、300 mg/kg的OPE对STZ诱导的糖尿病小鼠具有较好的降血糖、降血脂作用。
The effect of okra pectin(OPE)on streptozotocin(STZ)-induced type 2 diabetic mice was studied.A mice model of type 2 diabetes was induced by intraperitoneal STZ combined with a high-fat diet.After successful molding,the mice were given continuous drug administration for 10 d,the water intake,diet amount,body weight and fasting blood glucose of each group were monitored.The glucose tolerance,TC,TG,HDL,LDL,SOD,MDA and other indicators were also measured.The results showed that OPE could effectively regulate the typical symptoms of"three more and one less"in type 2 diabetic mice,reduce the blood glucose levels in diabetic mice(P<0.01),improve the abnormal glucose metabolism in diabetes mice,and reduce the related factors such as TC,TG,LDL-C,MDA in the serum of type 2 diabetic mice(P<0.01).It also elevated HDL and SOD factor levels(P<0.01),repaired liver tissue-cell morphology in diabetic mice.The conclusion was that 150 and 300 mg/kg OPE showed better control of blood sugar and lipids in STZ-induced diabetic mice.
作者
王璐
李蓓蓓
王参政
方柳影
刘苗苗
李彦灵
WANG Lu;LI Beibei;WANG Canzheng;FANG Liuying;LIU Miaomiao;LI Yanling(Sanquan College of Xinxiang Medical University,Xinxiang 453000)
出处
《中国食品添加剂》
CAS
北大核心
2023年第9期236-243,共8页
China Food Additives
基金
新乡医学院三全学院科学研究培育基金项目(XJKT201919)
新乡医学院三全学院优秀青年教师项目(SQ2021YQJH08、SQ2022YQJH08)
河南省科技攻关项目编号(222102310374)
河南省高等学校重点科研项目(20B350007)。
