摘要
环境内分泌干扰物(endocrine-disrupting chemicals,EDCs)普遍存在于日常生活中,其可通过改变内分泌系统的功能,进而损害人类的生殖健康。来自流行病学的研究发现,EDCs暴露可能增加卵巢功能提前减退的总体风险,导致卵巢储备功能减退、生育力或生殖力下降、月经周期不规律、更年期年龄提前和早发性卵巢功能不全。其机制可能通过改变受体介导的促凋亡通路、诱导信号转导和表观遗传修饰等导致卵巢卵泡发育受损。文章对EDCs与早发性卵巢功能不全的相关性以及作用机制作一总结,并探讨未来的研究方向。
Endocrine-disrupting chemicals(EDCs)are commonly present in daily life,which damage human reproductive health by altering the function of the endocrine system.Epidemiological studies have found that exposure to EDCs may increase the overall risk of early hypofunction of ovary,leading to the diminish of ovarian reserve,decline of fertility or fecundity,irregularity of the menstrual cycle,an earlier age at menopause,and premature ovarian insufficiency.Its mechanism may lead to impaired ovarian follicle development by altering receptor-mediated pro apoptotic pathways,inducing signal transduction,and epigenetic modifications.This article summarizes the correlation and mechanism of action between EDCs and premature ovarian insufficiency,and explores future research directions.
作者
舒宽勇
邓卫平
SHU Kuan-yong;DENG Wei-ping(Jiangxi Maternal and Child Health Hospital,Nanchang 330006,China)
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2023年第9期882-886,共5页
Chinese Journal of Practical Gynecology and Obstetrics
基金
江西省科技厅应用研究培育项目(20212BAG70045)。
