摘要
目的探索胃肝样腺癌临床病理特征,为临床提供参考。方法回顾性收集2014年4月至2022年7月于首都医科大学附属北京友谊医院确诊为胃肝样腺癌患者的临床病理资料,并进行生存分析。结果20例胃肝样腺癌患者中,男性占比85%,中位年龄为71岁,血清AFP、CEA阳性率分别为40%、25%;病理显示,上述患者中包含早期癌8例,进展期癌12例,淋巴结转移、脉管侵犯、肝转移和腹膜转移发生率分别为50%、35%、10%和5%;免疫组化染色显示,AFP、Glypican-3、SALL-4阳性率分别为40%、93.3%、40%。全组患者的3年总体生存率为70%,进展期癌3年总体生存率为50%,早期癌3年总体生存率为100%。结论胃肝样腺癌较早发生淋巴结转移、脉管侵犯及远处转移,预后较差。早期发现、早期治疗可提高患者生存质量、改善预后。
Objective To investigate the clinicopathological characteristics of patients with hepatoid adenocarcinoma of stomach(HAS).Methods The clinicopathological data and follow-up information of patients pathologically diagnosed as HAS from Apr.2014 to Jul.2022 in Beijing Friendship Hospital,Capital Medical University were retrospectively collected and analyzed.Results Among the 20 patients with HAS,85%were male and the median age was 71 years old at diagnosis.The positive rates of serum AFP and CEA before treatment were 40%and 25%.Histopathology indicated that 8 cases of early cancer and 12 cases of advanced cancer were included,and the incidence of lymph node metastasis,vascular invasion,liver metastasis and peritoneal metastasis were 50%,35%,10%and 5%,respectively.Immunohistochemical staining showed that the positive rates of AFP,Glypican-3 and SALL-4 were 40%,93.3%and 40%,respectively.The 3-year overall survival rate was 70%for the whole group,50%for advanced cancer,and 100%for early cancer.Conclusion HAS patients are prone to lymph node metastasis,vascular invasion and distant metastasis,and the prognosis is poor.Early detection and treatment can improve the survival and prognosis of patients with HAS.
作者
李文坤
崔子璐
李鹏
吴静
LI Wenkun;CUI Zilu;LI Peng;WU Jing(Department of Gastroenterology,Beijing Friendship Hospital,Capital Medical University,National Clinical Research Center for Digestive Diseases,Beijing Digestive Disease Center,Beijing 100050,China)
出处
《胃肠病学和肝病学杂志》
CAS
2023年第9期961-966,共6页
Chinese Journal of Gastroenterology and Hepatology
基金
首都卫生发展科研专项(首发2022-2-2025)
首都临床诊疗技术研究及转化应用(Z211100002921028)
首都医科大学附属北京友谊医院博导专项计划(YYDSZX201901)。
关键词
胃肝样腺癌
甲胎蛋白
临床病理特征
Hepatoid adenocarcinoma of stomach
Alpha-fetoprotein
Clinicopathological characteristics
