摘要
目的分析曲安奈德局部注射治疗肿块型肉芽肿性乳腺炎的有效性及安全性。方法回顾性分析2021年7月至2022年5月在西京医院就诊且满足纳入条件的67例肿块型肉芽肿性乳腺炎患者的病例资料,其中有31例患者选用曲安奈德局部注射治疗方案,另外36例则采用口服甲泼尼龙治疗方案,所有纳入患者在病情达到手术标准后均行手术治疗,随访时间截至术后半年。比较两个治疗组在症状、体征改善及治疗时间、临床有效性、安全性及复发率方面的差异性。结果曲安奈德注射组与甲泼尼龙口服组的有效率均为100%,但在分层分析中,曲安奈德组临床治愈占比明显高于甲泼尼龙组(P<0.05);曲安奈德组在症状、体征改善时间上较甲泼尼龙口服组明显缩短(P<0.05);曲安奈德组的不良反应发生例数也较甲泼尼龙组明显减少(P<0.05);在随访半年期间,两组均无复发病例。结论与传统口服甲泼尼龙组相比,曲安奈德局部注射治疗肿块型肉芽肿性乳腺炎能迅速缓解临床症状和体征,缩短治疗时间,有效率高且相关不良反应少。局部注射激素联合手术治疗肿块型肉芽肿性乳腺炎效果确切,复发率低。
Objective To analyze the efficacy and safety of intralesional triamcinolone acetonide in the treatment of mass granulomatous mastitis(GLM).Methods Retrospective analysis was made on 67 patients with GLM who were treated in Xijing Hospital from July 2021 to May 2022 and met the inclusion criteria.Among them,31 patients were treated with local injection of triamcinolone acetonide,while 36 ones were treated with oral methylprednisolone.All the included patients underwent surgical treatment after their condition met the surgical criteria,and the follow-up period lasted for up to six months after surgery.The two groups were compared in improvement of symptoms and signs,treatment time,clinical effectiveness and safety,and recurrence rate.Results The effective rate of triamcinolone acetonide group and methylprednisolone group was 100%,but the clinical cure rate was significantly higher in triamcinolone acetonide group than in methylprednisolone group in stratified analysis(P<0.05).The improvement time of symptoms and signs in triamcinolone acetonide group was significantly shorter than that in methylprednisolone group(P<0.05).The incidence of side effects in triamcinolone acetonide group was also significantly reduced compared to methylprednisolone group(P<0.05).Follow-up for half a year showed no recurrence in both groups.Conclusion Compared with the traditional oral methylprednisolone group,local injection of triamcinolone acetonide in the treatment of mass granulomatous mastitis can rapidly relieve clinical symptoms and signs,shorten treatment time,and has higher efficiency and fewer side effects.Local injection of hormone combined with surgery is effective in treating mass granulomatous mastitis with low recurrence rate.
作者
李彦杰
吕勇刚
季福庆
徐昕
贠军
易军
LI Yanjie;L Yonggang;JI Fuqing;XU Xin;YUN Jun;YI Jun(Department of Thyroid,Breast&Vascular Surgery,The First Affiliated Hospital of Air Force Medical University,Xi’an 710032;Department of Thyroid&Breast Surgery,Xi’an No.3 Hospital,The Affiliated Hospital of Northwest University of Xi’an,Xi’an 710018,China)
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2023年第5期773-778,共6页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
陕西省卫生研究基金项目(2022B003)。
关键词
曲安奈德
肉芽肿性乳腺炎
局部注射
疗效
triamcinolone acetonide
granulomatous mastitis
local injection
curative effect
