摘要
目的探讨特发性膜性肾病(IMN)患者尿液免疫球蛋白G4(IgG4)、白介素-17(IL-17)水平及其临床意义。方法选取2021年5月至2023年5月我院收治的68例IMN患者为观察组,选取同期70例健康者为对照组。检测两组的IgG4、IL-17水平,分析其与IMN的关系。结果观察组尿液IgG4、IL-17水平均高于对照组(P<0.05)。IgG4联合IL-17诊断IMN的AUC为0.986,高于IgG4的0.905以及IL-17的0.920(P<0.05)。IgG4、IL-17在Ⅰ期、Ⅱ期、Ⅲ期依次降低(P<0.05)。结论IMN患者IgG4、IL-17水平升高,二者与IMN病情关系密切,检测IgG4、IL-17水平有助于IMN的早期诊断。
Objective To explore the urinary immunoglobulin G4(IgG4)and interleukin-17(IL-17)levels in patients with idiopathic membranous nephropathy(IMN)and the clinical significance.Methods 68 IMN patients admitted to our hospital from May 2021 to May 2023 were selected as observation group,and 70 healthy people at the same period were selected as control group.The IgG4 and IL-17 levels of the two groups were detected,and the relationship among IgG4,IL-17 and IMN was analyzed.Results The urinary IgG4 and IL-17 levels of the observation group were higher than those of the control group(P<0.05).The AUC of IgG4 combined with IL-17 in the diagnosis of IMN was 0.986,higher than 0.905 of IgG4,and 0.920 of IL-17(P<0.05).IgG4 and IL-17 in stageⅠgroup,stageⅡgroup and stageⅢgroup decreased successively(P<0.05).Conclusions IgG4 and IL-17 levels in IMN patients increase,which are closely related to the disease condition of IMN.The detection of IgG4 and IL-17 levels is helpful for the early diagnosis of IMN.
作者
乔玲
杨翠丽
QIAO Ling;YANG Cuili(Clinical Laboratory,Xinxiang Peace Hospital,Xinxiang 453002,China)
出处
《临床医学工程》
2023年第9期1247-1248,共2页
Clinical Medicine & Engineering
