摘要
目的探讨加味枣仁汤治疗乳腺癌术后睡眠障碍的临床疗效。方法选取2020年6月—2021年7月期间于龙华医院中西结合乳腺科门诊就诊的126例乳腺癌术后以失眠或睡眠异常为主诉的患者作为研究对象,采用随机对照研究方法,分为对照组(62例)和观察组(64例)。对照组给予自拟乳腺癌术后方治疗,观察组给予加味枣仁汤治疗。治疗12周后,观察比较两组患者临床疗效、不良反应情况,治疗前后匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)、失眠严重程度指数量表(Insomnia Severity Index,ISI)、抑郁自评量表(Superoxide dismutase,SDS)、中医症状积分量表评分、血清[超氧化物歧化酶(Superoxide dismutase,SOD)、一氧化氮(NO)、总抗氧化能力(Total antioxidant capacity,T-AOC)]水平。结果治疗后观察组总有效率71.88%(46/64)明显高于对照组50.00%(31/62),差异有统计学意义(P<0.05)。治疗8、12周后,两组患者PSQI评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗12周后观察组PSQI评分明显低于对照组,差异有统计学意义(P<0.05)。治疗4周后,观察组ISI评分较治疗前降低,差异有统计学意义(P<0.05);对照组ISI评分与治疗前比较,差异无统计学意义(P>0.05);治疗8、12周后,两组患者ISI评分均较治疗前降低,差异有统计学意义(P<0.05);且观察组ISI评分明显低于对照组,差异有统计学意义(P<0.05)。治疗4、8、12周后观察组SDS评分较治疗前明显降低,差异有统计学意义(P<0.05),对照组无明显变化,观察组SDS评分较对照组明显降低,差异有统计学意义(P<0.05),观察组患者自治疗4周起抑郁状态明显改善,并恢复正常水平。治疗8、12周后观察组中医症状积分量表评分较治疗前、治疗4周降低,差异有统计学意义(P<0.05);且观察组中医症状积分量表评分低于对照组,差异有统计学意义(P<0.05)。治疗后观察组NO水平较治疗前降低,T-AOC水平较治疗�
Objective To investigate the clinical efficacy of modified Suanzaoren Decoction in treating sleep disorders after breast cancer surgery.Methods A total of 126 postoperative breast cancer patients with insomnia or sleep abnormalities who visited the Department of Breast Medicine,Longhua Hospital between June 2020 and July 2021 were enrolled and randomly divided into a control group(n=62)and an observation group(n=64).The control group received self-designed conventional postoperative treatment for breast cancer,while the observation group received treatment with modified Suanzaoren Decoction.After 12 weeks of treatment,the clinical efficacy and adverse reactions of the two groups were compared.The Pittsburgh Sleep Quality Index(PSQI),Insomnia Severity Index(ISI),Self-Rating Depression Scale(SDS),traditional Chinese medicine(TCM)symptom score,and serum levels of superoxide dismutase(SOD),nitric oxide(NO),and total antioxidant capacity(T-AOC)were evaluated before and after treatment.Results After treatment,the total effective rate in the observation group was 71.88%(46/64),significantly higher than 50.00%(31/62)in the control group(P<0.05).At 8 and 12 weeks of treatment,both groups showed significantly lower PSQI scores than those before treatment(P<0.05).Additionally,the PSQI score of the observation group was significantly lower than that of the control group at 12 weeks(P<0.05).After 4 weeks of treatment,the ISI score in the observation group decreased significantly compared with that before treatment(P<0.05),while there was no significant difference in ISI score of the control group before and after treatment(P>0.05).At 8 and 12 weeks of treatment,both groups showed significantly lower ISI scores than those before treatment(P<0.05),and the observation group was significantly lower than the control group(P<0.05).The SDS scores in the observation group decreased significantly at 4,8,and 12 weeks(P<0.05),while there were no significant changes in the control group.The SDS score of the observation group was signific
作者
鲍以嘉
刘胜
江雪沁
陈佳静
BAO Yi-jia;LIU Sheng;JIANG Xue-qin;CHEN Jia-jing(Department of Breast Medicine,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032;Jiangsu Health Vocational College,Nanjing Jiangsu 211800)
出处
《世界中西医结合杂志》
2023年第7期1406-1410,共5页
World Journal of Integrated Traditional and Western Medicine
基金
上海市科技计划项目(20Z21900300)
上海中医药大学附属龙华医院第二轮《促进市级医院临床技能与临床创新三年行动计划》重大临床研究项目(SHDC2020CR1050B)。
关键词
乳腺癌
睡眠障碍
酸枣仁汤
慢性应激
Breast Cancer
Sleep Disorders
Modified Suanzaoren Decoction
Chronic Stress
