摘要
目的本研究拟从炎症状态、细胞免疫、体液免疫水平,探讨粪钙卫蛋白(Fecal Calprotectin,FC)、IL6、IgG、IgA、T淋巴细胞亚群检测在溃疡性结肠炎(Ulcerative Colitis,UC)诊疗中的价值。方法选取2019年12月至2022年12月江西中医药大学附属医院肛肠科溃疡性结肠炎确诊病例103例,其中UC活动组46例,UC缓解组57例;另选同期正常对照组50例。检测FC、IL6、IgG、IgA、T淋巴细胞亚群,比较各组检测指标之间的差异及相关性,Logistic回归分析各检测指标与疾病进展的影响,ROC曲线分析各检测指标的疗效价值。结果UC对照组、UC缓解组、UC活动组比较,3组间年龄及性别差异无统计学意义(P>0.05);UC活动组中FC、IL6、IgA、CD3^(+)CD4^(+)(%)、CD3^(+)CD8^(+)(%)水平与UC缓解组、对照组差异有统计学意义(P<0.05),UC缓解组与对照组中仅FC比较差异有统计学意义(P<0.05);Logistic回归分析发现FC、IL6、IgA是溃疡性结肠炎进展的独立影响因素;比较活动组与缓解组ROC曲线发现,FC与IgG、CD3^(+)CD4^(+)(%)、CD3^(+)CD8^(+)(%)之间AUC比较差异有统计学意义(P<0.05),其余各指标间差异无统计学意义(P>0.05),选取FC、IL6、IgA联合检测,发现诊疗价值明显提升,除FC外,FC^(+)、IL6^(+)、IgA与IL6、IgG、IgA、CD3^(+)CD4^(+)(%)、CD3^(+)CD8^(+)(%)相比较差异有统计学意义(P<0.05)。结论粪钙卫蛋白在溃疡性结肠炎的诊断和评估中具有较好的价值,FC联合IgA、IL6三项同时检测,能有效评估溃疡性结肠炎的进展程度,有助于该疾病的早期干预和预防。
Objective This study intends to explore the value of detection of fecal calprotectin,IL6,IgG,IgA,and T lymphocyte subsets in the diagnosis and treatment of ulcerative colitis from the perspective of inflammatory state,cellular immunity,and humoral immunity.Methods From December 2019 to December 2022,103 confirmed cases of ulcerative colitis in the Anorectal Department of Jiangxi University of Traditional Chinese Medicine were selected,including 46 cases in the UC active group and 57cases in the UC remission group;50 cases in the normal control group were also selected during the same period.FC,IL6,IgG,I-gA,and T lymphocyte subsets were detected,and the differences and correlations between the detection indexes of each group were compared.Logistic regression was used to analyze the impact of each detection index on disease progression,and the ROC curve was used to analyze the curative effect of each detection index.Results Compared with the UC control group,UC remission group,and UC active group,there was no statistical difference in age and gender among the three groups (P>0.05);The levels of FC,IL6,IgA,CD3^(+)CD4^(+)(%),and CD3^(+)CD8^(+)(%) in the UC active group were significantly different from those in the UC remission group and the control group (P<0.05).Only FC in UC remission group and control group had statistical significance (P<0.05);Logistic regression analysis found that FC,IL6,IgA were independent factors affecting the progression of ulcerative colitis;Comparing the ROC curves of the active group and the remission group,it was found that there were statistically significant differences in AUC between FC and Ig G,CD3^(+)CD4^(+)(%),and CD3^(+)CD8^(+)(%)(P<0.05),there was no statistical difference among the other indicators(P<0.05),combined detection of FC,IL6,and IgA found that the value of diagnosis and treatment was significantly improved.Except for FC,FC^(+)IL6^(+)Ig A was significantly different from IL6,IgG,IgA,CD3^(+)CD4^(+)(%),CD3^(+)CD8^(+)(%)(P<0.05).Conclusion Fecal calprotectin has good val
作者
汪雯
杨军平
肖亮
WANG Wen;YANG Junping;XIAO Liang(Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Nanchang,330006,China)
出处
《江西医药》
CAS
2023年第7期781-785,共5页
Jiangxi Medical Journal
基金
江西省卫生健康委员会科技计划,编号20195326
国家自然科学基金地区项目,编号81860806。
