摘要
目的探讨肠系膜脂肪及爬行脂肪病变程度与克罗恩病穿透型和狭窄型疾病表型的相关性。方法回顾性分析2021年3月至2021年12月浙江大学医学院附属邵逸夫医院炎症性肠病中心101例行肠段切除的克罗恩病患者临床资料,分析不同疾病表型病变肠段的肠系膜脂肪、爬行脂肪、肠壁厚度、肠腔周径、肠道狭窄指数等特点,对狭窄型和穿透型克罗恩病肠系膜脂肪和爬行脂肪与病变肠段相关指标进行相关性分析。结果本组101例克罗恩病患者中狭窄型68例,穿透型33例。狭窄型克罗恩病患者肠系膜活动指数、肠管爬行脂肪程度显著高于穿透型患者(4.6±1.9比3.7±2.0,t=2.212,P=0.029;4.2±2.0比2.9±1.6,t=3.154,P=0.002);肠系膜及爬行脂肪病变程度与病变肠道狭窄指数、肠壁厚度、术前血清C反应蛋白、粪钙卫蛋白均呈正相关(均P<0.01),与肠腔最窄周径呈负相关(P<0.01)。结论狭窄型克罗恩病的肠系膜脂肪及爬行脂肪的病变程度较穿透型克罗恩病更加显著,肠系膜及爬行脂肪严重程度与肠壁厚度、肠腔狭窄程度、炎症指标密切相关。
Objective To analyze the relationship between mesenteric fat or creeping fat and bowel stricture or penetrating disease of Crohn's disease(CD).Methods Clinical data of 101 CD patients undergoing bowel surgery at Department of General Surgery in our hospital between Mar 2021 and Dec 2021 were retrospectively analyzed.The characteristics of mesenteric fat,creeping fat,luminal cross-section diameter,and the intestinal stricture index were analyzed.The Spearman correlation analysis was used to evaluate the correlation between disease behavior and mesenteric fat score or creeping fat score.Results Totally 101 CD patients were enrolled,with 68 stricturing diseases and 33 penetrating diseases.CD patients with stricturing diseases had higher score of mesenteric disease activity index(4.6±1.9 vs.3.7±2.0,t=2.212,P=0.029)and creeping fat index(4.2±2.0 vs.2.9±1.6,t=3.154,P=0.002)than those in patients with penetrating diseases.The mesenteric fat and creeping fat score positively correlated with the intestinal stricture index,C-reactive protein,and fecal calprotectin,and negatively correlated with minimum luminal cross-section diameter.Conclusion The higher score of mesenteric fat and creeping fat were observed in CD patients with stricturing disease,which were associated with intestinal stricture index and inflammation status.
作者
葛晓龙
白荣盘
戚卫林
刘威
吴燕
徐海利
叶玲娜
曹倩
周伟
Ge Xiaolong;Bai Rongpan;Qi Weilin;Liu Wei;Wu Yan;Xu Haili;Ye Lingna;Cao Qian;Zhou Wei(Department of General Surgery,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China;Department of Gastroenterology,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China)
出处
《中华普通外科杂志》
CSCD
北大核心
2023年第7期521-525,共5页
Chinese Journal of General Surgery
基金
国家自然科学基金(81800474)。
关键词
克罗恩病
脂肪
狭窄
穿透
Crohn's disease
Fat
Stricturing
Penetrating
