摘要
目的 探讨不同贫血类型患者铁蛋白水平、甲状腺功能检测结果对比分析。方法 前瞻性选取2018年11月—2021年11月我院收治的240例贫血患者作为研究对象。将患者分为小细胞低色素性贫血组(n=75),正细胞性贫血组(n=100)和大细胞性贫血组(n=65)。检查患者甲状腺功能[甲状腺素(TSH)、游离三碘甲腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))]和铁蛋白(SF)表达水平。采用Spearman检验进行相关性分析;采用Logistics回归模型进行回归分析。结果 3组患者红细胞(RBC)、血红蛋白(Hb)、平均红细胞容积(MCV)、红细胞平均血红蛋白浓度(MCHC)、平均红细胞血红蛋白含量(MCH)、血清肌酐(Scr)间存在差异(P<0.05);大细胞性贫血组TSH、FT_(3)和SF低于正细胞性贫血组和小细胞低色素性贫血组(P<0.05),而FT_(4)高于正细胞性贫血组和小细胞低色素性贫血组(P<0.05);贫血类型与TSH、FT_(4)、FT_(3)和SF呈正相关(P<0.05);多因素Logistics回归分析结果显示,TSH、FT_(4)、FT_(3)和SF在3个模型中均为独立危险因素(P<0.05)。结论 不同贫血类型患者间甲状腺功能和铁蛋白表达水平存在显著差异,大细胞性贫血组TSH、FT_(3)和SF低于正细胞性贫血组和小细胞低色素性贫血组,而FT_(4)更高,甲状腺功能指标和铁蛋白均是各种类型贫血发生的危险因素。
Objective To explore the comparative analysis of ferritin level and thyroid function detection results in patients with different types of anemia.Methods A total of 240 anemia patients admitted to our hospital from November 2018 to November 2021 were prospectively selected as research objects.The patients were divided into microcytic hypochromic anemia group(n=75),normocytic anemia group(n=100),and macrocytic anemia group(n=65).The expression levels of thyroid function[thyroxine(TSH),free triiodothyronine(FT_(3)),free thyroxine(FT_(4))]and ferritin(SF)were examined.Correlation analysis was performed by Sperman test.The logistic regression model was adopted for regression analysis.Results There were significant differences in red blood cell,hemoglobin,mean corpuscular volume,mean corpuscular hemoglobin concentration,mean corpuscular hemoglobin content and serum creatinine among three groups(P<0.05).TSH,FT_(3) and SF in macrocytic anemia group were significantly lower than those in normocytic anemia group and microcytic hypochromic anemia group(P<0.05),while FT_(4) was significantly higher than that in normocytic anemia group and microcytic hypochromic anemia group(P<0.05).The type of anemia was positively correlated with TSH,FT_(4),FT_(3) and SF(P<0.05).The results of multi-factor logistics regression analysis showed that TSH,FT_(4),FT_(3) and SF were independent risk factors in the three models(P<0.05).Conclusions There were significant differences in thyroid function and ferritin expression levels among patients with different types of anemia.Macrocytic anemia group TSH,FT_(3) and SF were lower than those in normocytic anemia group and microcytic hypochromic anemia group,while FT_(4) was higher.Both thyroid function indexes and ferritin were risk factors for various types of anemia.
作者
王华
牛琰
王瑞红
李领义
WANG Hua;NIU Yan;WANG Ruihong;LI Lingyi(Medical Laboratory,Xinxiang First People’s Hospital,Xinxiang 453000,China)
出处
《广州医药》
2023年第8期29-34,共6页
Guangzhou Medical Journal
关键词
不同贫血类型
铁蛋白
甲状腺功能
different types of anemia
ferritin
thyroid function
